Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8851
Título
Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer
Autor(es)
Butt, Julia | Fernandez de Larrea-Baz, Nerea ISCIII | Tjalsma, Harold | Roelofs, Rian | Kato, Ikuko | Martín, Vicente | Perez-Gomez, Beatriz ISCIII | Moreno, Victor | Dierssen-Sotos, Trinidad | Castilla Catalán, Jesús | Fernández-Tardón, Guillermo | Amiano, Pilar | Salas, Dolores | Alguacil, Juan | Jimenez-Moleon, Jose J. | Huerta, José María | de Sanjosé, Silvia | Del Campo, Rosa | Kogevinas, Manolis | Pollan-Santamaria, Marina ISCIII | Pawlita, Michael | Waterboer, Tim | Boleij, Annemarie | Aragones, Nuria ISCIII
Fecha de publicación
2019-07-26
Cita
Sci Rep. 2019 Jul 26;9(1):10847.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC and the CRC-specific interaction with antibodies to SGG proteins. Antibodies to FliC and SGG pilus proteins Gallo2178 and Gallo2179 were measured in two independent studies, a combined study from Nijmegen and Detroit (93 CRC cases, 74 controls) and a replication data set including 576 cases and 576 controls from the Spanish multicenter multicase-control study (MCC-Spain). Logistic regression was applied to assess whether antibodies to FliC were associated with CRC and modified the association of antibodies to SGG proteins with CRC. Antibodies to FliC were associated with those to SGG Gallo2178 among CRC cases, resulting in an interaction in the association of antibodies to Gallo2178 with CRC (p = 0.007). This association was only present among individuals with high antibody responses to FliC (OR: 2.42, 95% CI: 1.45-4.06). In conclusion, our findings suggest that colorectal tumorigenesis could be accompanied by an impaired integrity of the epithelium that could result in associated increased antibody responses to bacterial proteins.
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IRYCIS - Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > IIS > IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE) > ISCIII - Artículos