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dc.contributor.authorButt, Julia
dc.contributor.authorFernandez de Larrea, Nerea 
dc.contributor.authorTjalsma, Harold
dc.contributor.authorRoelofs, Rian
dc.contributor.authorKato, Ikuko
dc.contributor.authorMartín, Vicente
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorMoreno, Victor
dc.contributor.authorDierssen-Sotos, Trinidad
dc.contributor.authorCastilla, Jesús
dc.contributor.authorFernández-Tardón, Guillermo
dc.contributor.authorAmiano, Pilar
dc.contributor.authorSalas, Dolores
dc.contributor.authorAlguacil, Juan
dc.contributor.authorJiménez-Moleón, José Juan
dc.contributor.authorHuerta, José María
dc.contributor.authorde Sanjosé, Silvia
dc.contributor.authorDel Campo, Rosa
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorPawlita, Michael
dc.contributor.authorWaterboer, Tim
dc.contributor.authorBoleij, Annemarie
dc.contributor.authorAragones, Nuria 
dc.date.accessioned2019-12-20T11:49:25Z
dc.date.available2019-12-20T11:49:25Z
dc.date.issued2019-07-26
dc.identifier.citationSci Rep. 2019 Jul 26;9(1):10847.es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8851
dc.description.abstractAntibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC and the CRC-specific interaction with antibodies to SGG proteins. Antibodies to FliC and SGG pilus proteins Gallo2178 and Gallo2179 were measured in two independent studies, a combined study from Nijmegen and Detroit (93 CRC cases, 74 controls) and a replication data set including 576 cases and 576 controls from the Spanish multicenter multicase-control study (MCC-Spain). Logistic regression was applied to assess whether antibodies to FliC were associated with CRC and modified the association of antibodies to SGG proteins with CRC. Antibodies to FliC were associated with those to SGG Gallo2178 among CRC cases, resulting in an interaction in the association of antibodies to Gallo2178 with CRC (p = 0.007). This association was only present among individuals with high antibody responses to FliC (OR: 2.42, 95% CI: 1.45-4.06). In conclusion, our findings suggest that colorectal tumorigenesis could be accompanied by an impaired integrity of the epithelium that could result in associated increased antibody responses to bacterial proteins.es_ES
dc.description.sponsorshipWe thank Shaynoor Dramsi and Camille Danne (Department of Microbiology, Institut Pasteur, Paris, France) for providing the purified proteins Gallo2178 and Gallo2179. This work was supported by the National Institutes of Health (grant number R01-CA93817, Ikuko Kato); The Netherlands Organization for Scientific Research (NWO 016.166.089 to A.B.); the “Acción Transversal del Cáncer”, approved on the Spanish Ministry Council on the 11th October 2007; the Instituto de Salud Carlos III-FEDER funds –a way to build Europe- (grants numbers PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01662, PS09/01286, PS09/01903, PS09/02078, PI11/00226, PI11/01403, PI11/01810, PI11/01889, PI11/02213, PI12/00150, PI12/00265, PI12/00488, PI12/00715, PI12/01270, PI14/00613, PI17/00092); the Fundación Marques de Valdecilla (grant number API 10/09); Obra Social CAJASTUR (grant number SV-CAJASTUR-1); Recercaixa (grant number 2010ACUP 00310); Spanish Association Against Cancer (AECC) Scientific Foundation; Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) –Generalitat de Catalunya (Catalonian Government) (grant numbers 2009SGR1026, 2009SGR1465 and 2017SGR723); and Junta de Castilla y León (grant number LE022A10-2). Sample collection and storage was partially supported by the Instituto de Salud Carlos III-FEDER (grant number RD09/0076/00036), Xarxa de Bancs de Tumors de Catalunya sponsored by Pla Director d’Oncologia de Catalunya (XBTC).es_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAntibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal canceres_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31350458es_ES
dc.format.volume9es_ES
dc.format.number1es_ES
dc.format.page10847es_ES
dc.identifier.doi10.1038/s41598-019-47347-6es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundación Marqués de Valdecillaes_ES
dc.contributor.funderRecercaixaes_ES
dc.contributor.funderFundación Científica AECCes_ES
dc.contributor.funderAgencia de Gestio d'Ajuts Universitaris i de Recercaes_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderJunta de Castilla y Leónes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-47347-6es_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/R01-CA93817es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0533es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1359es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/00773es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01662es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01286es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/01270es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/00613es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/00092es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2010ACUP 00310es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2009SGR1026es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2009SGR1465es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2017SGR723es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/LE022A10-2es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD09/0076/00036es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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