2024-03-29T09:12:59Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/88512023-10-16T11:57:53Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16988col_20.500.12105_16983col_20.500.12105_16981col_20.500.12105_16974col_20.500.12105_16970col_20.500.12105_16968col_20.500.12105_16962col_20.500.12105_16959col_20.500.12105_2054
00925njm 22002777a 4500
dc
Butt, Julia
author
Fernandez de Larrea-Baz, Nerea
author
Tjalsma, Harold
author
Roelofs, Rian
author
Kato, Ikuko
author
Martín, Vicente
author
Perez-Gomez, Beatriz
author
Moreno, Victor
author
Dierssen-Sotos, Trinidad
author
Castilla Catalán, Jesús
author
Fernández-Tardón, Guillermo
author
Amiano, Pilar
author
Salas, Dolores
author
Alguacil, Juan
author
Jimenez-Moleon, Jose J.
author
Huerta, José María
author
de Sanjosé, Silvia
author
Del Campo, Rosa
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Pawlita, Michael
author
Waterboer, Tim
author
Boleij, Annemarie
author
Aragones, Nuria
author
2019-07-26
Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC and the CRC-specific interaction with antibodies to SGG proteins. Antibodies to FliC and SGG pilus proteins Gallo2178 and Gallo2179 were measured in two independent studies, a combined study from Nijmegen and Detroit (93 CRC cases, 74 controls) and a replication data set including 576 cases and 576 controls from the Spanish multicenter multicase-control study (MCC-Spain). Logistic regression was applied to assess whether antibodies to FliC were associated with CRC and modified the association of antibodies to SGG proteins with CRC. Antibodies to FliC were associated with those to SGG Gallo2178 among CRC cases, resulting in an interaction in the association of antibodies to Gallo2178 with CRC (p = 0.007). This association was only present among individuals with high antibody responses to FliC (OR: 2.42, 95% CI: 1.45-4.06). In conclusion, our findings suggest that colorectal tumorigenesis could be accompanied by an impaired integrity of the epithelium that could result in associated increased antibody responses to bacterial proteins.
Sci Rep. 2019 Jul 26;9(1):10847.
2045-2322
http://hdl.handle.net/20.500.12105/8851
31350458
10.1038/s41598-019-47347-6
2045-2322
Scientific reports
Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer