El Instituto de Salud Carlos III es el principal Organismo Público de Investigación (OPI), que financia, gestiona y ejecuta la investigación biomédica en España. Con una trayectoria de más de 20 años de investigación en ciencias de la vida y de la salud y prestación de servicios de referencia, es además el organismo gestor de la Acción Estratégica en Salud (AES) en el marco del Plan Nacional de I+D+I. Adscrito orgánicamente al Ministerio de Ciencia, Innovación y Universidades (Real Decreto 865/2018) y funcionalmente, tanto a este como al Ministerio de Sanidad, Consumo y Bienestar Social (Real Decreto 1047/2018), tiene como misión principal el fomento de la generación de conocimiento científico en ciencias de la salud y el impulso de la innovación en la atención sanitaria y en la prevención de la enfermedad. Situando al paciente y a la ciudadanía en el centro de todos sus objetivos y actividades, fomenta y coordina la investigación Biomédica y ofrece Servicios Científico-Técnicos de la más alta calidad, en colaboración con todos los agentes del Sistema Español de Ciencia, Tecnología e Innovación.

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Clinical and genetic characterization of patients with eye diseases included in the Spanish Rare Diseases Patient Registry 

Background: The low prevalence of rare diseases poses a significant challenge in advancing their understanding. This study aims to delineate the clinical and genetic characteristics of patients with rare eye diseases (RED) enrolled in the Spanish Rare Diseases Patient Registry. Methods: A total of ...

“Thanks to my activists Friends”: a qualitative study of perspectives of young adults and professionals on the factors related to seeking support among victims of sexual violence in Spain 

Background: Sexual violence (SV) is a public health problem with high prevalence among the young population. The use of formal resources for SV care (e.g. institutional services) is low in this age group. This study applies a framework of health assets to identify the factors that positively influe...

Prevalence and social determinants of smoking among men in Mauritius: a cross-sectional study 

Background: Mauritius has implemented a range of stringent policies to control smoking and promote public health. Regular monitoring focuses on the prevalence of tobacco use, yet there is a gap in understanding its socio-economic patterns. Objective: The aim of this study was to estimate the preval...

HIV diagnosis in Equatorial Guinea. Keys to reduce the diagnostic and therapeutic delay 

Background: In Equatorial Guinea, only 54 % of people living with HIV know their HIV status. There are no confirmatory or molecular diagnostic techniques for early diagnosis or monitoring of infection in the country. Rapid diagnostic tests can induce false-positive diagnoses if used as a confirmato...

A low dose of curcumin-PDA nanoparticles improves viability and proliferation in endoneurial fibroblasts and Schwann cell cultures 

Curcumin is a polyphenol extracted from Curcuma longa's roots. Low doses of curcumin are related to anti-inflammatory, antioxidant, and neuroprotective effects, while high doses are used for their lethality. This diversity of behaviors allows us to understand curcumin as a compound with hormetic ac...

Contributing to the management of viral infections through simple immunosensing of the arachidonic acid serum level 

A trendsetting direct competitive-based biosensing tool has been developed and implemented for the determination of the polyunsaturated fatty acid arachidonic acid (ARA), a highly significant biological regulator with decisive roles in viral infections. The designed methodology involves a competiti...

Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes 

Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor stability issues, the limitations in determining tox...

Surveillance of invasive pneumococcal disease in Spain exploring the impact of the COVID-19 pandemic (2019-2023) 

Objectives: Dynamic trends of invasive pneumococcal disease (IPD) including the evolution of prevalent serotypes are very useful to evaluate the impact of current and future pneumococcal conjugate vaccines (PCVs) and the rise of non-vaccine serotypes. In this study, we include epidemiological patte...

Female authorship positions in health economic evaluations: a cross-sectional analysis 

[EN] Objective: To investigate the gender of the authors who publish articles of health economic evaluations in medicine and healthcare journals. Method: We evaluated a random sample of economic evaluations indexed in MEDLINE during 2019. Gender of the first, last and corresponding author was deter...

Public interest in drug-related problems reflected in information search trends: an infodemiological study 

Background: The analysis of how people search and "navigate" the internet to obtain health-related information and how they communicate and share this information can provide valuable knowledge about the disease patterns behaviour and health habits of populations. Objective: To determine the popula...

Sleep patterns, sleep disorders and mammographic density in spanish women: The DDM-Spain/Var-DDM study 

We explored the relationship between sleep patterns and sleep disorders and mammographic density (MD), a marker of breast cancer risk. Participants in the DDM-Spain/var-DDM study, which included 2878 middle-aged Spanish women, were interviewed via telephone and asked questions on sleep characterist...

The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019 

Background: The European Union (EU) faces many health-related challenges. Burden of diseases information and the resulting trends over time are essential for health planning. This paper reports estimates of disease burden in the EU and individual 27 EU countries in 2019, and compares them with thos...

The Role of Environmental Factors in Lyme Disease Transmission in the European Union: A Systematic Review 

Background: Lyme disease (LD) is an emergent vector-borne disease caused by Borrelia spp. and transmitted through infected ticks, mainly Ixodes spp. Our objective was to determine meteorological and environmental factors associated with LD transmission in Europe and the effect of climate change on ...

Conservation of HLA Spike Protein Epitopes Supports T Cell Cross-Protection in SARS-CoV-2 Vaccinated Individuals against the Potentially Zoonotic Coronavirus Khosta-2 

Heterologous vaccines, which induce immunity against several related pathogens, can be a very useful and rapid way to deal with new pandemics. In this study, the potential impact of licensed COVID-19 vaccines on cytotoxic and helper cell immune responses against Khosta-2, a novel sarbecovirus that ...

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project 

In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While the public expects chemicals and products to be safe for the...

Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU 

Phthalates and the substitute plasticizer DINCH belong to the first group of priority substances investigated by the European Human Biomonitoring Initiative (HBM4EU) to answer policy-relevant questions and safeguard an efficient science-to-policy transfer of results. Human internal exposure levels ...

Exploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022-23 VEBIS multicentre study in Europe 

Background: Within influenza vaccine effectiveness (VE) studies at primary care level with a laboratory-confirmed outcome, clinical case definitions for recruitment of patients can vary. We used the 2022-23 VEBIS primary care European multicentre study end-of-season data to evaluate whether the cli...

Drug-facilitated sexual assault in youth nightlife contexts in Spain 

Objectives: This study aimed to provide epidemiological information on drug-facilitated sexual assault in Spanish youth partying, with a focus on prevalence rates and associated sociodemographic factors. Study design: Cross-sectional study: Methods: Quota sampling was used to recruit 1601 young peo...

Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis 

OBJECTIVE: Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS: We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had n...