El Instituto de Salud Carlos III es el principal Organismo Público de Investigación (OPI), que financia, gestiona y ejecuta la investigación biomédica en España. Con una trayectoria de más de 20 años de investigación en ciencias de la vida y de la salud y prestación de servicios de referencia, es además el organismo gestor de la Acción Estratégica en Salud (AES) en el marco del Plan Nacional de I+D+I. Adscrito orgánicamente al Ministerio de Ciencia, Innovación y Universidades (Real Decreto 865/2018) y funcionalmente, tanto a este como al Ministerio de Sanidad, Consumo y Bienestar Social (Real Decreto 1047/2018), tiene como misión principal el fomento de la generación de conocimiento científico en ciencias de la salud y el impulso de la innovación en la atención sanitaria y en la prevención de la enfermedad. Situando al paciente y a la ciudadanía en el centro de todos sus objetivos y actividades, fomenta y coordina la investigación Biomédica y ofrece Servicios Científico-Técnicos de la más alta calidad, en colaboración con todos los agentes del Sistema Español de Ciencia, Tecnología e Innovación.

Sub-communities within this community

Recent Submissions

Association of disability with mortality in the Spanish adult non-institutionalized population 

Background. There is limited information about the association between disability and all-cause and cause-specific mortality among community-dwelling adults. Methods. We used baseline data from 162,381 adults who participated in a countrywide disability survey in 2008. A nationally representative ...

Cost-Effectiveness of an Exercise Programme That Provided Group or Individual Training to Reduce the Fall Risk in Healthy Community-Dwelling People Aged 65-80: A Secondary Data Analysis. 

Research has demonstrated that some exercise programs are effective for reducing fall rates in community-dwelling older people; however, the literature is limited in providing clear recommendations of individual or group training as a result of economic evaluation. The objective of this study was t...

Perception of risk of exposure in the management of hazardous drugs in home hospitalization and hospital units. 

To assess the perception of risk of exposure in the management of hazardous drugs (HDs) through home hospitalization and hospital units. A questionnaire was released, at the national level, to health professionals with HD management expertise. Questionnaire included 21 questions that were scored u...

EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway. 

Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS-FLI1. We report that EWS-FLI1 suppresses TDO2-mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS-FLI1-dependent regulation of TRP metabolism. TRP consumption incr...

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors. 

The endocannabinoid (eCB) system, via the cannabinoid CB1 receptor, regulates neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB1 receptor signalling in vivo drives corticofugal deep layer projection neuron development through the regulation of BCL11B and SATB2 tra...

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors. 

The endocannabinoid (eCB) system, via the cannabinoid CB1 receptor, regulates neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB1 receptor signalling in vivo drives corticofugal deep layer projection neuron development through the regulation of BCL11B and SATB2 tra...

A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease. 

Tauopathies, including Alzheimer's disease (AD) and frontotemporal lobar degeneration with Tau pathology (FTLD-tau), are a group of neurodegenerative disorders characterized by Tau hyperphosphorylation. Post-translational modifications of Tau such as phosphorylation and truncation have been demonst...

Spanish adaptation and validation of the Pain Assessment Scale in Advanced Dementia (PAINAD) in patients with dementia and impaired verbal communication: cross-sectional study. 

The aim of this study was to adapt and validate the Pain Assessment in Advanced Dementia (PAINAD) scale in Spanish. Cross-sectional observational study. Two health districts of Andalusian provinces, located in the south of Spain, through the Andalusian network of Primary Healthcare centres and fo...

The Global Spine Care Initiative: care pathway for people with spine-related concerns. 

The purpose of this report is to describe the development of an evidence-based care pathway that can be implemented globally. The Global Spine Care Initiative (GSCI) care pathway development team extracted interventions recommended for the management of spinal disorders from six GSCI articles that...

Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. 

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare congenital form of heterotopic ossification (HO), caused by heterozygous mutations in the activin A type I receptor (ACVR1), that encodes the bone morphogenetic protein (BMP) type I receptor ALK2. These mutations enable ALK2 to induce...

Autistic Adult Health and Professional Perceptions of It: Evidence From the ASDEU Project 

The Autism Spectrum Disorders in the European Union (ASDEU) survey investigated the knowledge and health service experiences of users and providers to generate new hypotheses and scientific investigations that would contribute to improvement in health care for autistic adults. An online survey desi...

sta-1 is repressed by mir-58 family in Caenorhabditis elegans. 

The miR-58 family comprises 6 microRNAs with largely shared functions, and with an overall high expression, because one of its members, miR-58, is the most abundant microRNA in Caenorhabditis elegans. We recently found that 2 TGF-β signaling pathways, Sma/Mab and Dauer, responsible for body size an...

Polymerization of misfolded Z alpha-1antitrypin protein lowers CX3CR1 expression in human PBMCs. 

The CX3CR1 (chemokine (C-X3-C motif) receptor 1) expression levels on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions. The factors implicated in the regulation of CX3CR1 and its specific ligand CX3CL1 (fractalkine) expressio...

Normalized medical information visualization 

A new mark-up programming language is introduced in order to facilitate and improve the visualization of ISO/EN 13606 dual model-based normalized medical information. This is the first time that visualization of normalized medical information is addressed and the programming language is intended to...

Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring 

Although the exposure assessment of chemicals of emerging concern (CECs) has taken a decisive step forward through advances in (bio)informatics, statistics, and the development of highly sophisticated analytical instruments, the lack of standardisation and harmonisation of analytical workflows and ...

Late presentation for HIV remains a major health issue in Spain: Results from a multicenter cohort study, 2004-2018. 

With the purpose of reducing the well-known negative impact of late presentation (LP) on people living with HIV (PLWH), guidelines on early HIV diagnosis were published in 2014 in Spain, but since then no data on LP prevalence have been published. To estimate prevalence and risk factors of LP and t...

Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers 

Elite and viremic HIV controllers are able to control their HIV infection and maintain undetectable or low-level viremia in the absence of antiretroviral treatment. Despite extensive studies, the immune factors responsible for such exclusive control remain poorly defined. We identified a cohort of ...

Knowledge and experiences of Chagas disease in Bolivian women living in Spain: a qualitative study. 

In Europe, Spain has the highest number of people with Chagas disease (CD). Bolivian migrants account for 81% of the reported cases. One of the priorities in controlling the disease is prevention of mother-to-child transmission. Despite under-diagnosis in Spain being estimated at 90%, there are cur...

Screening for autism spectrum disorders: state of the art in Europe. 

A large number of studies have reported on the validity of autism spectrum disorder (ASD) screening procedures. An overall understanding of these studies' findings cannot be based solely on the level of internal validity of each, since screening instruments might perform differently according to ce...

Consecuencias en la Producción Científica de la Covid-19. 

[ES] El impacto y la universalidad de la pandemia de SARS-CoV-2 han provocado en el mundo entero la necesidad de disponer de información científica de una forma rápida y accesible para la correcta toma de decisiones entre los profesionales sanitarios. Por ello, en 10 meses la producción ci...