Artículos, contribuciones a congresos, datos de investigación, libros, capítulos de libro, patentes, tesis y trabajos de investigación.

Sub-communities within this community

  • ISCIII [2250]

    Instituto de Salud Carlos III
  • CNIC [950]

    Centro Nacional de Investigaciones Cardiovasculares
  • CNIO [400]

    Centro Nacional de Investigaciones Oncológicas

Recent Submissions

DNA methylation and cancer incidence: lymphatic-hematopoietic versus solid cancers in the Strong Heart Study. 

Epigenetic alterations may contribute to early detection of cancer. We evaluated the association of blood DNA methylation with lymphatic-hematopoietic cancers and, for comparison, with solid cancers. We also evaluated the predictive ability of DNA methylation for lymphatic-hematopoietic cancers. B...

Toll-Like Receptors in Acute Kidney Injury. 

Acute kidney injury (AKI) is an important health problem, affecting 13.3 million individuals/year. It is associated with increased mortality, mainly in low- and middle-income countries, where renal replacement therapy is limited. Moreover, survivors show adverse long-term outcomes, including increa...

Pneumococcal Choline-Binding Proteins Involved in Virulence as Vaccine Candidates. 

Streptococcus pneumoniae is a pathogen responsible for millions of deaths worldwide. Currently, the available vaccines for the prevention of S. pneumoniae infections are the 23-valent pneumococcal polysaccharide-based vaccine (PPV-23) and the pneumococcal conjugate vaccines (PCV10 and PCV13). These...

Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples. 

Candida tropicalis is a human pathogen that primarily infects the immunocompromised. Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in 2009, there have been no large-scale, multi-isolate studies of the genetic and phenotypic diversity of this species. Here, we u...

Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation 

Aging and age-related diseases are strong risk factors for the development of neurodegenerative diseases. Neuroinflammation (NIF), as the brain's immune response, plays an important role in aged associated degeneration of central nervous system (CNS). There is a need for well characterized animal m...

Low sensitivity of conventional fungal agars in fungemia by Rhodotorula mucilaginosa: description of two cases 

Although most bloodstream yeast infections are caused by Candida spp., infections by rare or less common species have increased in recent years. Diagnosis of infections caused by these species is difficult due to the lack of specific symptoms and adequate diagnostic tools. We describe two cases of...

Obtaining EHR-derived datasets for COVID-19 research within a short time: a flexible methodology based on Detailed Clinical Models. 

COVID-19 ranks as the single largest health incident worldwide in decades. In such a scenario, electronic health records (EHRs) should provide a timely response to healthcare needs and to data uses that go beyond direct medical care and are known as secondary uses, which include biomedical research...

Recommendations from the European Commission Initiative on Breast Cancer for multigene testing to guide the use of adjuvant chemotherapy in patients with early breast cancer, hormone receptor positive, HER-2 negative. 

Predicting the risk of recurrence and response to chemotherapy in women with early breast cancer is crucial to optimise adjuvant treatment. Despite the common practice of using multigene tests to predict recurrence, existing recommendations are inconsistent. Our aim was to formulate healthcare reco...

The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation. 

Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK a...

Detection of asymptomatic Leishmania infection in Bangladesh by antibody and antigen diagnostic tools shows an association with post-kala-azar dermal leishmaniasis (PKDL) patients. 

Asymptomatic Leishmania infections outnumber clinical infections on the Indian subcontinent (ISC), where disease reservoirs are anthroponotic. Diagnostics which detect active asymptomatic infection, which are suitable for monitoring and surveillance, may be of benefit to the visceral leishmaniasis ...

Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017-2018. 

The main etiologic agent of tuberculosis (TB) in livestock is Mycobacterium bovis; human TB cases caused by M. bovis are rare. Analysis of a TB outbreak caused by polyresistant M. bovis involving a human and sympatric sheep in Spain suggests local circulation of drug-resistant M. bovis strains amon...

Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma. 

Osteosarcoma is the most common malignant solid tumor that affects bones, however, survival rates of patients with relapsed osteosarcoma have not improved in the last 30 years. Oncolytic virotherapy, which uses viruses designed to selectively replicate in cancer cells, has emerged as a promising tr...

Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain. 

COVID-19 is a zoonotic disease caused by SARS-CoV-2. Infections of animals with SARS-CoV-2 have recently been reported, and an increase of severe lung pathologies in domestic dogs has also been detected by veterinarians in Spain. Therefore, further descriptions of the pathological processes in thos...

Magnitud y factores asociados al fenómeno de la muerte solitaria del anciano en la Comunidad Valenciana 

[ES] En la Comunidad Valenciana un 23% de los ancianos viven solos, representando la muer-te solitaria del anciano un efecto indeseado del envejeci-miento. Nuestro objetivo fue determinar la magnitud de este fenómeno y sus factores de riesgo en la población mayor de 64 años d...

New circulation of genotype V of Crimean-Congo haemorrhagic fever virus in humans from Spain. 

Crimean-Congo haemorrhagic fever (CCHF) is a widespread tick-borne viral disease caused by the Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV has been implicated in severe viral haemorrhagic fever outbreaks. During the summer of 2016, the first two cases with genotype III (Africa 3) were rep...

Proteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling. 

Low-grade, early-stage endometrial carcinoma (EC) is the most frequent malignant tumor of the uterine corpus. However, the molecular alterations that underlie these tumors are far from being fully understood. The purpose of this study is to describe dysregulated molecular pathways from EC patients....

Assessment of the Nutritional Status, Diet and Intestinal Parasites in Hosted Saharawi Children. 

Since the early 1990s, Spanish humanitarian associations have welcomed Saharawi children from the refugee camps in Tindouf (Argelia). These children are the most affected by the lack of food, water, hygienic measures and health care. The main objective of this study was to analyze the anthropometri...

Reduced prevalence of soil-transmitted helminths and high frequency of protozoan infections in the surrounding urban area of Curitiba, Paraná, Brazil. 

Human populations living in the surrounding urban areas of large Brazilian cities have increased vulnerability to intestinal parasites. However, the epidemiological scenario of soil-transmitted helminths (STH) in Curitiba, Paraná's main city, remains largely unknown. To bridge this gap of knowledge...

Genotipado de Giardia duodenalis, Cryptosporidium spp. y Blastocystis sp. en población escolar asintomática 

Los protozoos Giardia duodenalis y Cryptosporidium spp., el estramenopilo Blastocystis sp. y el microsporidio Enterocytozoon bieneusi son algunos de los parásitos entéricos causantes de diarrea más relevantes en salud pública humana. Este estudio epidemiológico molecular investiga la diversidad gen...

Epidemiología de los enteroparásitos Giardia duodenalis, Cryptosporidium spp. y Blastocystis sp. en población escolar asintomática 

Los protozoos entéricos Giardia duodenalis y Cryptosporidium spp. son importantes agentes causantes de diarrea en niños en todo el mundo, mientras que el estramenopilo Blastocystis sp. ha sido asociado con síndrome de colon irritable y trastornos cutáneos. Este estudio investiga la presencia y los ...