Artículos, contribuciones a congresos, datos de investigación, libros, capítulos de libro, patentes, tesis y trabajos de investigación.

Sub-communities within this community

  • ISCIII [2454]

    Instituto de Salud Carlos III
  • CNIC [1052]

    Centro Nacional de Investigaciones Cardiovasculares
  • CNIO [417]

    Centro Nacional de Investigaciones Oncológicas

Recent Submissions

Análisis comparativo de la inmunidad humoral natural y artificial del sars-cov-2 en trabajadores de asistencia sanitaria del instituto nacional de gestión sanitaria de Ceuta 

La pandemia de COVID-19 ha justificado una necesidad urgente de comprender tanto la inmunidad mediada por vacunas como la inducida por la infección; así como la duración y eficacia de la misma. Esto puede permitir un adecuado seguimiento de la respuesta inmunitaria individual, incluida la evaluaci...

Transformar la enfermería a través del conocimiento. Desarrollo de guías de buenas prácticas, ciencia de la implantación, y evaluación. 

Este libro nació de un profundo deseo de compartir nuestra experiencia en el desarrollo de un programa de Práctica Clínica Basada en la Evidencia (PCBE) de clase mundial que ha logrado resultados excepcionales a través del uso de las Guías de Buenas Practicas (GBP), transformando la práctica de las...

The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes. 

Ewing sarcoma is a rare pediatric tumor characterized by chromosomal translocations that give rise to aberrant chimeric transcription factors (e.g., EWSR1-FLI1). EWSR1-FLI1 promotes a specific cellular transcriptional program. Therefore, the study of EWSR1-FLI1 target genes is important to identify...

Association of disability with mortality in the Spanish adult non-institutionalised population 

Background: There are scant studies focused on measuring the association between disability and all-cause mortality based on large representative national samples of the community-dwelling adult population; moreover, the number of such studies which also include cause-specific mortality is yet lowe...

Influencia del uso de guantes en la higiene de manos y factores que modifican su efecto 

La Seguridad del Paciente, componente clave de la calidad asistencial, ha adquirido gran relevancia en los últimos años tanto para los pacientes y sus familias, como para los gestores y profesionales que desean ofrecer una asistencia sanitaria segura, efectiva y eficiente. Una infección asociada a ...

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism 

Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph node pre-metastatic niche formation in murine models. We found that small EVs (sEVs) derived from metastatic melanoma cell lin...

Changes in food intake, smoking habits and physical activity before and one year after the end of the COVID-19 lockdown in Spanish population of 20 to 30 years of age 

[EN] Introduction: The COVID-19 pandemic, that initiated in Wuhan, China presenting its first case on the 17th of November 2019 and in Spain on the 31st of January 2019, represented a massive impact on human health. Not only was the health of the world population affected, but also their lifestyles...

Physical Restraint Use in Intensive Care Units: Exploring the Decision-Making Process and New Proposals. A Multimethod Study. 

The general aim of this study was to explore the decision-making process followed by Intensive Care Unit (ICU) health professionals with respect to physical restraint (PR) administration and management, along with the factors that influence it. A qual-quant multimethod design was sequenced in two ...

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. 

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all ava...

Influence of Nutrition, Food and Diet-Related Interventions in the Workplace: A Meta-Analysis with Meta-Regression. 

To review the scientific literature on the influence of verified nutrition, food and diet interventions on occupational health. This study involved a critical analysis of articles retrieved from MEDLINE (via PubMed), Embase, Cochrane Library, PsycINFO, Scopus, Web of Science, Latin American and Ca...

Co-creation methodology with smart technologies in health and well-being to enable communication between isolated and disperse small communities: a literature review [Dataset] 

Objective: the objective is to determine reported cases of co-creation methodology about the use of smart technologies in public spaces in order to create new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication be...

Lymphoproliferative response after stimulation with soluble leishmania antigen (SLA) as a predictor of visceral leishmaniasis (VL) relapse in HIV+ patients. 

The introduction of HAART resulted in the decrease of Leishmania/HIV co-infection cases; nevertheless, the number of relapses remains high and secondary prophylaxis is recommended. However, secondary prophylaxis is not necessary in all patients, and presents a high risk of toxicity and an elevated ...

Retrospective Identification of Early Autochthonous Case of Crimean-Congo Hemorrhagic Fever, Spain, 2013 

Before this report, 7 autochthonous human cases of Crimean-Congo hemorrhagic fever had been reported in Spain, all occurring since 2016. We describe the retrospective identification of an eighth case dating back to 2013. This study highlights that the earliest cases of an emerging disease are often...

Is It Feasible to Use CMV-Specific T-Cell Adoptive Transfer as Treatment Against Infection in SOT Recipients? 

During the last decade, many studies have demonstrated the role of CMV specific T-cell immune response on controlling CMV replication and dissemination. In fact, it is well established that transplanted patients lacking CMV-specific T-cell immunity have an increased occurrence of CMV replication ep...

Frecuencia e impacto de eventos adversos en un hospital de tercer nivel. Estudio ESHMAD 

Introducción: los Eventos Adversos (EA) son uno de los principales problemas de la asistencia sanitaria, ya que derivada de ésta se produce un daño innecesario al paciente, físico y psicológico, que además genera sobrecostes al sistema sanitario. Objetivos: conocer la prevalencia de EA del Hospital...

Exposición hormonal intraútero y riesgo de cáncer de mama y de próstata (estudio MCC-Spain) 

Introducción: el cáncer de mama y de próstata son los tumores más frecuentes en mujeres y hombres respectivamente en España. Son tumores hormonodependientes y el grado de exposición hormonal condiciona su evolución. Algunas hipótesis plantean que las exposiciones del periodo prenatal condicionan la...

Evaluaciones económicas de la vacunación estacional de la gripe: una revisión sistemática 

Introducción: Las evaluaciones económicas de los programas de vacunación de la gripe parecen mostrar, en general, que este tipo de intervenciones son beneficiosas para la sociedad en términos clínicos y económicos. Sin embargo, parece que existen ciertos factores que hacen que la efectividad de lo...

La Atención Primaria en España 30 años tras su implantación: Revisión sistemática de alcance sobre planes y nuevas estrategias 

Introducción y objetivos: En los últimos años, varias Comunidades Autónomas han diseñado planes estratégicos para reasignar a la Atención Primaria de Salud (APS) un lugar primordial dentro del sistema sanitario tras años de deterioro. Esta revisión realiza una descripción del panorama de dichos pla...

Evaluación de la formación sobre el programa de optimización del uso de antimicrobianos en médicos residentes de la provincia de Las Palmas 

Contexto. La resistencia a los antibióticos es una amenaza para la salud pública mundial. Esta situación hace imprescindible el establecimiento de programas de optimización del uso de antimicrobianos (PROA). Se identifican las necesidades formativas en el PROA de los médicos residentes y se exponen...

Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance. 

Evidence suggests that aging-related dysfunctions of adipose tissue and metabolic disturbances increase the risk of diabetes and metabolic syndrome (MtbS), eventually leading to cognitive impairment and dementia. However, the neuroprotective role of adipocytokines in this process has not been speci...