Artículos, contribuciones a congresos, datos de investigación, libros, capítulos de libro, patentes, tesis y trabajos de investigación.

Sub-communities within this community

  • ISCIII [2441]

    Instituto de Salud Carlos III
  • CNIC [1052]

    Centro Nacional de Investigaciones Cardiovasculares
  • CNIO [416]

    Centro Nacional de Investigaciones Oncológicas

Recent Submissions

Frecuencia e impacto de eventos adversos en un hospital de tercer nivel. Estudio ESHMAD 

Introducción: los Eventos Adversos (EA) son uno de los principales problemas de la asistencia sanitaria, ya que derivada de ésta se produce un daño innecesario al paciente, físico y psicológico, que además genera sobrecostes al sistema sanitario. Objetivos: conocer la prevalencia de EA del Hospital...

Exposición hormonal intraútero y riesgo de cáncer de mama y de próstata (estudio MCC-Spain) 

Introducción: el cáncer de mama y de próstata son los tumores más frecuentes en mujeres y hombres respectivamente en España. Son tumores hormonodependientes y el grado de exposición hormonal condiciona su evolución. Algunas hipótesis plantean que las exposiciones del periodo prenatal condicionan la...

Evaluaciones económicas de la vacunación estacional de la gripe: una revisión sistemática 

Introducción: Las evaluaciones económicas de los programas de vacunación de la gripe parecen mostrar, en general, que este tipo de intervenciones son beneficiosas para la sociedad en términos clínicos y económicos. Sin embargo, parece que existen ciertos factores que hacen que la efectividad de lo...

La Atención Primaria en España 30 años tras su implantación: Revisión sistemática de alcance sobre planes y nuevas estrategias 

Introducción y objetivos: En los últimos años, varias Comunidades Autónomas han diseñado planes estratégicos para reasignar a la Atención Primaria de Salud (APS) un lugar primordial dentro del sistema sanitario tras años de deterioro. Esta revisión realiza una descripción del panorama de dichos pla...

Evaluación de la formación sobre el programa de optimización del uso de antimicrobianos en médicos residentes de la provincia de Las Palmas 

Contexto. La resistencia a los antibióticos es una amenaza para la salud pública mundial. Esta situación hace imprescindible el establecimiento de programas de optimización del uso de antimicrobianos (PROA). Se identifican las necesidades formativas en el PROA de los médicos residentes y se exponen...

Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance. 

Evidence suggests that aging-related dysfunctions of adipose tissue and metabolic disturbances increase the risk of diabetes and metabolic syndrome (MtbS), eventually leading to cognitive impairment and dementia. However, the neuroprotective role of adipocytokines in this process has not been speci...

Vigilancia de las enfermedades raras en España: el Registro Estatal de Enfermedades Raras 

[ES] Tradicionalmente la vigilancia epidemiológica se ha centrado en enfermedades transmisibles, pero el concepto de vigilancia en Salud Pública, incorporado en España con la Ley 33/2011, es más amplio e incluye las enfermedades crónicas. Las estrategias de salud para estas enfermedad...

Polybacterial mucosal vaccine protects against viral respiratory infections and induces trained immunity 

Recurrent respiratory tract infections (RRTI) are very frequent in childhood due to the immature state of the immune system and the traditional therapeutic strategies just rely on antibiotic treatments. However, the etiology of RRTIs is diverse, with viruses being the most common cause of the disea...

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity. 

Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. Forty Large-White pigs were included. In Study 1, 20...

The Embryonic Key Pluripotent Factor NANOG Mediates Glioblastoma Cell Migration via the SDF1/CXCR4 Pathway. 

NANOG is a key transcription factor required for maintaining pluripotency of embryonic stem cells. Elevated NANOG expression levels have been reported in many types of human cancers, including lung, oral, prostate, stomach, breast, and brain. Several studies reported the correlation between NANOG e...

Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles. 

Imaging of the lymphatic vasculature has gained great attention in various fields, not only because lymphatic vessels act as a key draining system in the body, but also for their implication in autoimmune diseases, organ transplant, inflammation and cancer. Thus, neolymphangiogenesis, or the genera...

Corrientes renovadoras en la Didáctica de las Ciencias Naturales y su influencia en la Salud Pública. Educación Ambiental y Educación para la Salud 1876-1936 

Cuando las poblaciones sufren convulsiones políticas, económicas o de otro orden y se ven inmersas en tiempos prolongados de depresión económica o, desempleo de gran parte de la población es necesario buscar una motivación para conseguí nuevas metas. Los dos últimos siglos, XIX y XX, se han caracte...

Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C. 

ECM composition and architecture are tightly regulated for tissue homeostasis. Different disorders have been associated to alterations in the levels of proteins such as collagens, fibronectin (FN) or tenascin-C (TnC). TnC emerges as a key regulator of multiple inflammatory processes, both during ph...

Effectiveness of anakinra for tocilizumab-refractory severe COVID-19: A single-centre retrospective comparative study. 

A subgroup of patients with SARS-CoV-2 infection was thought to have developed cytokine release syndrome and were treated with tocilizumab; however, a significant percentage of patients evolved. This study aimed to determine the usefulness of anakinra as a rescue treatment for patients with tociliz...

Venous lactate improves the prediction of in-hospital adverse outcomes in normotensive pulmonary embolism. 

Arterial lactate is an established risk marker in patients with pulmonary embolism (PE). However, its clinical applicability is limited by the need of an arterial puncture. In contrast, venous lactate can easily be measured from blood samples obtained via routine peripheral venepuncture. We invest...

microRNA Fine-Tuning of the Germinal Center Response. 

Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. ...

Is Energy Expenditure or Physical Activity Considered When Energy Intake Is Measured? A Scoping Review 1975-2015. 

The health-transitions humans have delivered during the 20th Century associated with the nutrition is that from undernutrition to obesity, which perseveres in the current years of the 21st Century. Energy intake (EI) is a contributing factor and therefore a fascination in nutritional sciences. Howe...

Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. 

Chromosomal instability (CIN) is a hallmark of cancer1. Yet, many childhood cancers, such as Ewing sarcoma (EwS), feature remarkably 'silent' genomes with minimal CIN2. Here, we show in the EwS model how uncoupling of mitosis and cytokinesis via targeting protein regulator of cytokinesis 1 (PRC1) o...

Intervention Services for Autistic Adults: An ASDEU Study of Autistic Adults, Carers, and Professionals' Experiences. 

The Autism Spectrum Disorders in the European Union (ASDEU) survey investigated local services' use experiences of autistic adults, carers and professionals with interventions for autistic adults. The majority of the 697 participants experienced recommended considerations prior to deciding on inter...

ΔNp73, TAp73 and Δ133p53 Extracellular Vesicle Cargo as Early Diagnosis Markers in Colorectal Cancer. 

The early diagnosis of colorectal cancer is a key factor in the overall survival of the patients. The actual screening programs include different approaches with significant limitations such as unspecificity, high invasiveness, and detection at late stages of the disease. The specific content of ex...