IIS
La Ley 14/2007, de 3 de julio, de investigación biomédica, establece en su artículo 88 que el Sistema Nacional de Salud (en adelante SNS) colaborará con otras instituciones y organizaciones implicadas en la investigación para la utilización conjunta de infraestructuras científicas y el desarrollo de proyectos de investigación. A tal efecto, se promoverá la configuración de institutos de investigación biomédica en el seno de los centros del SNS mediante la asociación de grupos de investigación. En desarrollo de la previsión anterior, el Real Decreto 279/2016, de 24 de junio, sobre acreditación de institutos de investigación biomédica o sanitaria, establece los requisitos y la regulación del procedimiento para la acreditación de institutos de investigación biomédica o sanitaria en el ámbito del SNS. Los seis primeros Institutos de Investigación Sanitaria se acreditaron en el año 2009. A finales de 2010 ya eran diez los IIS acreditados. En 2011 se sumaron otros seis; dos más en 2012; otros cuatro en 2014; siete en 2015; en 2019 se incorporaron otros dos; en 2020 se sumó otro. En el período 2021 a 2022 se sumaron uno más por año. Actualmente, son 35 los IIS acreditados y se prevé que pueda ir incrementándose con la incorporación de aquellos institutos que reúnan los criterios necesarios, para seguir expandiendo el modelo de IIS.
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HIV diagnosis in Equatorial Guinea. Keys to reduce the diagnostic and therapeutic delay
Background: In Equatorial Guinea, only 54 % of people living with HIV know their HIV status. There are no confirmatory or molecular diagnostic techniques for early diagnosis or monitoring of infection in the country. Rapid diagnostic tests can induce false-positive diagnoses if used as a confirmato...
Surveillance of invasive pneumococcal disease in Spain exploring the impact of the COVID-19 pandemic (2019-2023)
Objectives: Dynamic trends of invasive pneumococcal disease (IPD) including the evolution of prevalent serotypes are very useful to evaluate the impact of current and future pneumococcal conjugate vaccines (PCVs) and the rise of non-vaccine serotypes. In this study, we include epidemiological patte...
Female authorship positions in health economic evaluations: a cross-sectional analysis
[EN] Objective: To investigate the gender of the authors who publish articles of health economic evaluations in medicine and healthcare journals. Method: We evaluated a random sample of economic evaluations indexed in MEDLINE during 2019. Gender of the first, last and corresponding author was deter...
Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease
Background: Patients with chronic obstructive pulmonary disease (COPD) can be classified into groups A/C or B/D based on symptom intensity. Different threshold values for symptom questionnaires can result in misclassification and, in turn, different treatment recommendations. The primary aim was to...
Direct oral anticoagulants in patients with hypertrophic cardiomyopathy and atrial fibrillation
Background: Chronic anticoagulation with vitamin K antagonists (VKAs) is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Direct oral anticoagulants (NOACs) are an alternative to VKAs but there are limited data to support their use in HCM. We sought to de...
Geographical variation in therapy for bloodstream infections due to multidrug-resistant Enterobacteriaceae: a post-hoc analysis of the INCREMENT study
We describe regional differences in therapy for bloodstream infection (BSI) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) or carbapenemase-producing Enterobacteriaceae (CPE). Patients (n = 1482) in 12 countries from an observational study of BSI caused by ESBL-E o...
Screening for generalized anxiety disorder in Spanish primary care centers with the GAD-7
The aim of the study was to determine the criterion validity of a computerized version of the General Anxiety Disorder-7 (GAD-7) questionnaire to detect general anxiety disorder in Spanish primary care centers. A total of 178 patients completed the GAD-7 and were administered the Composite Internat...
Pathogen reduction/inactivation of products for the treatment of bleeding disorders: what are the processes and what should we say to patients?
Patients with blood disorders (including leukaemia, platelet function disorders and coagulation factor deficiencies) or acute bleeding receive blood-derived products, such as red blood cells, platelet concentrates and plasma-derived products. Although the risk of pathogen contamination of blood pro...
Sleep patterns, sleep disorders and mammographic density in spanish women: The DDM-Spain/Var-DDM study
We explored the relationship between sleep patterns and sleep disorders and mammographic density (MD), a marker of breast cancer risk. Participants in the DDM-Spain/var-DDM study, which included 2878 middle-aged Spanish women, were interviewed via telephone and asked questions on sleep characterist...
Integrated assessment of infant exposure to persistent organic pollutants and mercury via dietary intake in a central western Mediterranean site (Menorca Island)
In this research the levels of organochlorine compounds (OCs) and mercury (Hg) in several food items from Menorca Island were presented. The dietary exposure assessment was performed in children population from the island. Finally, body burden of OCs and Hg in these infants were associated with the...
Long-term intake of a high-protein diet increases liver triacylglycerol deposition pathways and hepatic signs of injury in rats
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathw...
Associations between Both Lignan and Yogurt Consumption and Cardiovascular Risk Parameters in an Elderly Population: Observations from a Cross-Sectional Approach in the PREDIMED Study
Background The study of dietary patterns is gaining interest. Although the health benefits of yogurt and lignans have been investigated separately, to our knowledge there are no studies on their associative effects. Objective The aim of this study was to evaluate a possible association between yogu...
Is car use related with successful aging of older adults ? Results from the multinational Mediterranean islands study
Purpose: The aim of the present work was to evaluate the relation between car use and the level of successful aging of a random sample of older adults living in the Mediterranean basin. Methods: During 2005-2011, 2749 older (aged 65-100 years) from 22 islands and the rural Mani region (Peloponnesus...
Is Parental Longevity Associated With the Cardiovascular Risk and the Successful Aging of Their Offspring? Results From the Multinational MEDIS Study
The aim of the present study was to evaluate the role of parental longevity and parental cardiovascular disease (CVD) history in CVD risk and successful aging of a random sample of older adults living in the Mediterranean basin and who participated in the MEDiterranean Islands (MEDIS) study. During...
Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line
Objective: Staphylococcus aureus is a particularly difficult pathogen to eradicate from the respiratory tract. Previous studies have highlighted the intracellular capacity of S. aureus in several phagocytic and non-phagocytic cells. The aim of this study was to define S. aureus interaction within a...
Hemobilia due to intracholecystic papillary neoplasm
[EN] We report the case of a 39-year-old patient who presented an episode of upper gastrointestinal bleeding due to hemobilia. The imaging tests showed the gallbladder occupied by solid tissue, with a diagnosis of intracholecystic papillary neoplasm after the cholecystectomy. The intracholecystic p...
Risk of thrombosis according to need of phlebotomies in patients with polycythemia vera treated with hydroxyurea
Hematocrit control below 45% is associated with a lower rate of thrombosis in polycythemia vera. In patients receiving hydroxyurea, this target can be achieved with hydroxyurea alone or with the combination of hydroxyurea plus phlebotomies. However, the clinical implications of phlebotomy requireme...