Now showing items 1-20 of 3533

    Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma. 

    Osteosarcoma is the most common malignant solid tumor that affects bones, however, survival rates of patients with relapsed osteosarcoma have not improved in the last 30 years. Oncolytic virotherapy, which uses viruses designed to selectively replicate in cancer cells, has emerged as a promising tr...

    Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain. 

    COVID-19 is a zoonotic disease caused by SARS-CoV-2. Infections of animals with SARS-CoV-2 have recently been reported, and an increase of severe lung pathologies in domestic dogs has also been detected by veterinarians in Spain. Therefore, further descriptions of the pathological processes in thos...

    Magnitud y factores asociados al fenómeno de la muerte solitaria del anciano en la Comunidad Valenciana 

    [ES] En la Comunidad Valenciana un 23% de los ancianos viven solos, representando la muer-te solitaria del anciano un efecto indeseado del envejeci-miento. Nuestro objetivo fue determinar la magnitud de este fenómeno y sus factores de riesgo en la población mayor de 64 años d...

    New circulation of genotype V of Crimean-Congo haemorrhagic fever virus in humans from Spain. 

    Crimean-Congo haemorrhagic fever (CCHF) is a widespread tick-borne viral disease caused by the Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV has been implicated in severe viral haemorrhagic fever outbreaks. During the summer of 2016, the first two cases with genotype III (Africa 3) were rep...

    Proteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling. 

    Low-grade, early-stage endometrial carcinoma (EC) is the most frequent malignant tumor of the uterine corpus. However, the molecular alterations that underlie these tumors are far from being fully understood. The purpose of this study is to describe dysregulated molecular pathways from EC patients....

    Assessment of the Nutritional Status, Diet and Intestinal Parasites in Hosted Saharawi Children. 

    Since the early 1990s, Spanish humanitarian associations have welcomed Saharawi children from the refugee camps in Tindouf (Argelia). These children are the most affected by the lack of food, water, hygienic measures and health care. The main objective of this study was to analyze the anthropometri...

    Reduced prevalence of soil-transmitted helminths and high frequency of protozoan infections in the surrounding urban area of Curitiba, Paraná, Brazil. 

    Human populations living in the surrounding urban areas of large Brazilian cities have increased vulnerability to intestinal parasites. However, the epidemiological scenario of soil-transmitted helminths (STH) in Curitiba, Paraná's main city, remains largely unknown. To bridge this gap of knowledge...

    Genotipado de Giardia duodenalis, Cryptosporidium spp. y Blastocystis sp. en población escolar asintomática 

    Los protozoos Giardia duodenalis y Cryptosporidium spp., el estramenopilo Blastocystis sp. y el microsporidio Enterocytozoon bieneusi son algunos de los parásitos entéricos causantes de diarrea más relevantes en salud pública humana. Este estudio epidemiológico molecular investiga la diversidad gen...

    Epidemiología de los enteroparásitos Giardia duodenalis, Cryptosporidium spp. y Blastocystis sp. en población escolar asintomática 

    Los protozoos entéricos Giardia duodenalis y Cryptosporidium spp. son importantes agentes causantes de diarrea en niños en todo el mundo, mientras que el estramenopilo Blastocystis sp. ha sido asociado con síndrome de colon irritable y trastornos cutáneos. Este estudio investiga la presencia y los ...

    Métodos para la evaluación económica de programas de cribado neonatal. 

    [ES] Los programas de cribado neonatal son una herramienta fun-damental para la prevención secundaria o detección presintomáti-ca de determinadas afecciones. La implantación de un programa de cribado neonatal requiere necesariamente de una evaluación de su efectividad, seguridad, coste-efe...

    Effect of health-promoting messages in television food commercials on adolescents' attitudes and consumption: A randomized intervention study. 

    The HAVISA plan is a Spanish government's policy for the promotion of healthy lifestyles via health messages in television food advertisements. This study evaluated the positive or negative impact (health halo effect) of health messages on food choices and predisposition towards healthy habits of S...

    Parasites of the Reintroduced Iberian Lynx (Lynx pardinus) and Sympatric Mesocarnivores in Extremadura, Spain. 

    The Iberian lynx (Lynx pardinus) is one of the most endangered felid species in the world. Conservation efforts have increased its population size and distribution and reinforced their genetic diversity through captive breeding and reintroduction programmes. Among several threats that the Iberian l...

    Multilocus Genotyping of Giardia duodenalis in Mostly Asymptomatic Indigenous People from the Tapirapé Tribe, Brazilian Amazon. 

    Little information is available on the occurrence and genetic variability of the diarrhoea-causing enteric protozoan parasite Giardia duodenalis in indigenous communities in Brazil. This cross-sectional epidemiological survey describes the frequency, genotypes, and risk associations for this pathog...

    Fatal Case of Crimean-Congo Hemorrhagic Fever Caused by Reassortant Virus, Spain, 2018. 

    In August 2018, a fatal autochthonous case of Crimean-Congo hemorrhagic fever was confirmed in western Spain. The complete sequence of the viral genome revealed circulation of a new virus because the genotype differs from that of the virus responsible for another case in 2016. Practitioners should ...

    The Value of Mouse Models of Rare Diseases: A Spanish Experience. 

    Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alter...

    NF-kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol. 

    Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown. Here, we performed in silico analysis to investigate signaling alterations in cardiomyocytes induced by inhalational [sev...

    Fluorescence-Based Nanoparticle Tracking Analysis and Flow Cytometry for Characterization of Endothelial Extracellular Vesicle Release. 

    As extracellular vesicles (EVs) have become a prominent topic in life sciences, a growing number of studies are published on a regular basis addressing their biological relevance and possible applications. Nevertheless, the fundamental question of the true vesicular nature as well as possible influ...

    Nuclear imaging approaches facilitating nanomedicine translation. 

    Nanomedicine approaches can effectively modulate the biodistribution and bioavailability of therapeutic agents, improving their therapeutic index. However, despite the ever-increasing amount of literature reporting on preclinical nanomedicine, the number of nanotherapeutics receiving FDA approval r...

    Lockdown measures and relative changes in the age-specific incidence of SARS-CoV-2 in Spain. 

    The first months of the SARS-CoV-2 epidemic in Spain resulted in high incidence and mortality. A national sero-epidemiological survey suggests higher cumulative incidence of infection in older individuals than in younger individuals. However, little is known about the epidemic dynamics in different...

    Occurrence and Genetic Diversity of Protist Parasites in Captive Non-Human Primates, Zookeepers, and Free-Living Sympatric Rats in the Córdoba Zoo Conservation Centre, Southern Spain. 

    Little information is currently available on the epidemiology of parasitic and commensal protist species in captive non-human primates (NHP) and their zoonotic potential. This study investigates the occurrence, molecular diversity, and potential transmission dynamics of parasitic and commensal prot...