IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
El Instituto de Investigación Biomédica de Bellvitge (IDIBELL) es un centro de investigación en biomedicina participado por el Hospital Universitario de Bellvitge y el Hospital de Viladecans del Instituto Catalán de la Salud, el Instituto Catalán de Oncología, la Universidad de Barcelona y el Ayuntamiento de l’Hospitalet de Llobregat. En 2017, el Centro de Medicina Regenerativa de Barcelona (CMR[B]), ahora parte del IDIBELL, inicia el despliegue del Programa de Traslación Clínica de Medicina Regenerativa de Cataluña (P-CMR[C]) con el IDIBELL. Los focos de investigación del IDIBELL son el cáncer, las neurociencias, la medicina traslacional y la medicina regenerativa. La investigación, la innovación y la sociedad son los pivotes sobre los que los investigadores trabajan cada día para mejorar la calidad de vida de los ciudadanos y ciudadanas. Acreditado por el Instituto de Salud Carlos III como Instituto de Investigación Sanitaria en 2009, y renovando esta acreditación cada 5 años, forma parte así del total de 34 Institutos de Investigación Sanitaria acreditados existentes en la actualidad.
Envíos recientes
SEOM clinical guidelines for the management of germ cell testicular cancer (2016)
Testicular cancer represents the most common malignancy in males aged 15-34 years and is considered a model of curable neoplasm. Maintaining success, reducing treatment burden, and focusing on survivorship are then key objectives. Inguinal orchiectomy is the first recommended maneuver that has both...
Predictors of short- and long-term adherence with a Mediterranean-type diet intervention: the PREDIMED randomized trial
Background: Dietary intervention success requires strong participant adherence, but very few studies have examined factors related to both short-term and long-term adherence. A better understanding of predictors of adherence is necessary to improve the design and execution of dietary intervention t...
Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naive-to-memory B-cell transition
Common variable immunodeficiency (CVID), the most frequent primary immunodeficiency characterized by loss of B-cell function, depends partly on genetic defects, and epigenetic changes are thought to contribute to its aetiology. Here we perform a high-throughput DNA methylation analysis of this diso...
Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study
Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance wi...
Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study
Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change...
Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation
Background: Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD. Methods: The PAC-COPD cohort included 342 COPD patients hospitalised for the first time for an exacerbation of COPD (2004-2006). ...
Draft Genome Sequence of the Quorum-Sensing and Biofilm-Producing Pseudomonas aeruginosa Strain Pae221, Belonging to the Epidemic High-Risk Clone Sequence Type 274
Pseudomonas aeruginosa Pae221 is a clinical isolate from blood culture. Pae221 was found to be a strong quorum-sensing and biofilm-producing strain and also demonstrates a notable production of phenazines. This strain belongs to sequence type 274 (ST274), an epidemic high-risk clone. Here, we repor...
Daptomycin plus fosfomycin versus daptomycin monotherapy in treating MRSA: protocol of a multicentre, randomised, phase III trial
Introduction: Despite the availability of new antibiotics such as daptomycin, methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia continues to be associated with high clinical failure rates. Combination therapy has been proposed as an alternative to improve outcomes but there is a lack o...
Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of ...
Ratio índice/anular (proxy de exposición hormonal intraútero) y riesgo de cáncer de próstata (MCC-Spain)
Antecedentes/Objetivos: La hipótesis de la programación fetal plantea que las exposiciones durante el periodo prenatal afectan la salud del adulto. En esta línea, la exposición hormonal intrauterina (EHI) podría relacionarse con el riesgo de cáncer de próstata (CP). Un marcador propuesto para estud...
Biomarkers for personalised prevention of chronic diseases: a common protocol for three rapid scoping reviews
Introduction: Personalised prevention aims to delay or avoid disease occurrence, progression, and recurrence of disease through the adoption of targeted interventions that consider the individual biological, including genetic data, environmental and behavioural characteristics, as well as the socio...
Interactive Gap Maps on Available Biomarkers for Risk Prediction and Stratification in Cancer, Cardiovascular, and Neurodegenerative Diseases (PROPHET Project)
[EN] The PROPHET project (“PeRsOnalized Prevention roadmap for the future HEalThcare”), funded by the European Union's Horizon Europe research and innovation program, aims to assess the effectiveness, clinical utility, key success factors, and gaps in personalised preventive approaches for healthca...
High adherence to Western dietary pattern increases breast cancer risk (an EPIC-Spain study)
Objective: To explore the association between three previously identified and validated dietary patterns (Western, Prudent and Mediterranean) and breast cancer risk by tumour subtype and menopausal status. Methods: Data from the Spanish cohort of the European Prospective Investigation into Cancer a...
Adaptation and validation of the Physical Restraint-Theory of Planned Behaviour Questionnaire to the paediatric context
Objective: To create and test psychometrically a paediatric version of the Physical Restraint-Theory of Planned Behaviour Questionnaire to assess paediatric critical care nurses' intention to use physical restraint. Design: A psychometric study. Setting: Five medical-surgical Paeditric Intensive ca...
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study...
Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study.
Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (S...
Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing.
Patients with Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are at high risk of developing major adverse cardiovascular events (MACE). This is a multicenter, retrospective, and observational study performed in Spain aimed to characterize these patients in a real-world setting. U...
Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome.
Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficient...
Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome.
Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Older adults with overweight/obesity and metabolic syndr...