Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20117
Título
Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study
Autor(es)
Romaguera, Dora | Ward, Heather | Wark, Petra A. | Vergnaud, Anne-Claire | Peeters, Petra H | van Gils, Carla H | Ferrari, Pietro | Fedirko, Veronika | Jenab, Mazda | Boutron-Ruault, Marie-Christine | Dossus, Laure | Dartois, Laureen | Hansen, Camilla Plambeck | Dahm, Christina Catherine | Buckland, Genevieve | Sanchez, Maria Jose | Dorronsoro, Miren | Navarro, Carmen | Barricarte, Aurelio | Key, Timothy J | Trichopoulou, Antonia | Tsironis, Christos | Lagiou, Pagona | Masala, Giovanna | Pala, Valeria | Tumino, Rosario | Vineis, Paolo | Panico, Salvatore | Bueno-de-Mesquita, H. Bas | Siersema, Peter D | Ohlsson, Bodil | Jirstrom, Karin | Wennberg, Maria | Nilsson, Lena M | Weiderpass, Elisabete | Kuehn, Tilman | Katzke, Verena | Khaw, Kay-Tee | Wareham, Nick J | Tjonneland, Anne | Boeing, Heiner | Quiros, Jose R | Gunter, Marc J | Riboli, Elio | Norat, Teresa
Fecha de publicación
2015-05-07
Cita
Romaguera D, Ward H, Wark Petra A, Vergnaud AC, Peeters Petra H, Van Gils CH, et al. Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study. BMC Med. 2015 May 07;13:107.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. Methods: The association between the WCRF/AICR score (score range 0-6 in men and 0-7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Results: The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7) categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and 0.70 (0.56-0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0-2/0-3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models. Conclusions: Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.
Palabras clave
MESH
Aged, 80 and over | Aged | European Continental Ancestry Group | Adult | Humans | Life Style | Middle Aged | Diet | Male | Prospective Studies | Patient Compliance | Female | Colorectal Neoplasms | Proportional Hazards Models | Cohort Studies | Incidence
DECS
Estudios de Cohortes | Incidencia | Modelos de Riesgos Proporcionales | Neoplasias Colorrectales | Femenino | Dieta | Grupo de Ascendencia Continental Europea | Masculino | Cooperación del Paciente | Humanos | Persona de Mediana Edad | Estudios Prospectivos | Estilo de Vida | Anciano | Anciano de 80 o más Años | Adulto
Versión en línea
DOI
Aparece en las colecciones
Acceso a texto completo