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dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | Ward, Heather | |
dc.contributor.author | Wark, Petra A. | |
dc.contributor.author | Vergnaud, Anne-Claire | |
dc.contributor.author | Peeters, Petra H | |
dc.contributor.author | van Gils, Carla H | |
dc.contributor.author | Ferrari, Pietro | |
dc.contributor.author | Fedirko, Veronika | |
dc.contributor.author | Jenab, Mazda | |
dc.contributor.author | Boutron-Ruault, Marie-Christine | |
dc.contributor.author | Dossus, Laure | |
dc.contributor.author | Dartois, Laureen | |
dc.contributor.author | Hansen, Camilla Plambeck | |
dc.contributor.author | Dahm, Christina Catherine | |
dc.contributor.author | Buckland, Genevieve | |
dc.contributor.author | Sanchez, Maria Jose | |
dc.contributor.author | Dorronsoro, Miren | |
dc.contributor.author | Navarro, Carmen | |
dc.contributor.author | Barricarte, Aurelio | |
dc.contributor.author | Key, Timothy J | |
dc.contributor.author | Trichopoulou, Antonia | |
dc.contributor.author | Tsironis, Christos | |
dc.contributor.author | Lagiou, Pagona | |
dc.contributor.author | Masala, Giovanna | |
dc.contributor.author | Pala, Valeria | |
dc.contributor.author | Tumino, Rosario | |
dc.contributor.author | Vineis, Paolo | |
dc.contributor.author | Panico, Salvatore | |
dc.contributor.author | Bueno-de-Mesquita, H. Bas | |
dc.contributor.author | Siersema, Peter D | |
dc.contributor.author | Ohlsson, Bodil | |
dc.contributor.author | Jirstrom, Karin | |
dc.contributor.author | Wennberg, Maria | |
dc.contributor.author | Nilsson, Lena M | |
dc.contributor.author | Weiderpass, Elisabete | |
dc.contributor.author | Kuehn, Tilman | |
dc.contributor.author | Katzke, Verena | |
dc.contributor.author | Khaw, Kay-Tee | |
dc.contributor.author | Wareham, Nick J | |
dc.contributor.author | Tjonneland, Anne | |
dc.contributor.author | Boeing, Heiner | |
dc.contributor.author | Quiros, Jose R | |
dc.contributor.author | Gunter, Marc J | |
dc.contributor.author | Riboli, Elio | |
dc.contributor.author | Norat, Teresa | |
dc.date.accessioned | 2024-07-04T12:55:01Z | |
dc.date.available | 2024-07-04T12:55:01Z | |
dc.date.issued | 2015-05-07 | |
dc.identifier.citation | Romaguera D, Ward H, Wark Petra A, Vergnaud AC, Peeters Petra H, Van Gils CH, et al. Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study. BMC Med. 2015 May 07;13:107. | en |
dc.identifier.issn | 1741-7015 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10845 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20117 | |
dc.description.abstract | Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. Methods: The association between the WCRF/AICR score (score range 0-6 in men and 0-7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Results: The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7) categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and 0.70 (0.56-0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0-2/0-3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models. Conclusions: Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients. | en |
dc.description.sponsorship | We would like to acknowledge the contribution of all participants in the study. This study was funded by the World Cancer Research Fund (WCRF) International Regular Grant Programme (Grant number 2009/44). Dora Romaguera holds a Ramon y Cajal contract (Ministerio de Economia y Competitividad, Spain and European Regional Development Fund; RYC-2011-08796). In addition, EPIC investigators acknowledge funding from the following agencies: Europe Against Cancer Program of the European Commission (SANCO); German Cancer Aid; German Cancer Research Center (DKFZ); German Federal Ministry of Education and Research (BMBF); Danish Cancer Society; Catalan Institute of Oncology, Spain; Health Research Fund (FIS) of the Spanish Ministry of Health; Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia (no. 6236) and Navarra; ISCIII RCESP exp. C03/09 and ISCIII RETICC RD06/0020/0091, Spain; Cancer Research UK; Medical Research Council, United Kingdom; The Hellenic Health Foundation, Greece; Italian Association for Research on Cancer (AIRC); Italian National Research Council; Fondazione-Istituto Banco Napoli, Italy; Dutch Ministry of Public Health, Welfare and Sports, Dutch Prevention Funds, LK Research Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), The Netherlands; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skane, Sweden; Helga-Nordic Center of Excellence Programme in Nutrition and Health; French League against Cancer (LNCC); National Institute for Health and Medical Research (INSERM), France; Mutuelle Generale de l'Education Nationale (MGEN), France; 3 M Co., France; Gustave Roussy Institute (IGR), France; and General Councils of France. | es_ES |
dc.language.iso | eng | en |
dc.publisher | BioMed Central (BMC) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Colorectal cancer | en |
dc.subject | Diet | en |
dc.subject | Healthy lifestyle | en |
dc.subject | Physical activity | en |
dc.subject | Survival | en |
dc.subject | Weight | en |
dc.subject.mesh | Aged, 80 and over | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | European Continental Ancestry Group | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Life Style | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Diet | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Prospective Studies | * |
dc.subject.mesh | Patient Compliance | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Colorectal Neoplasms | * |
dc.subject.mesh | Proportional Hazards Models | * |
dc.subject.mesh | Cohort Studies | * |
dc.subject.mesh | Incidence | * |
dc.title | Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 25948112 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.page | 107 | es_ES |
dc.identifier.doi | 10.1186/s12916-015-0332-5 | |
dc.relation.publisherversion | https://dx.doi.org/10.1186/s12916-015-0332-5 | en |
dc.identifier.journal | BMC Medicine | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Estudios de Cohortes | * |
dc.subject.decs | Incidencia | * |
dc.subject.decs | Modelos de Riesgos Proporcionales | * |
dc.subject.decs | Neoplasias Colorrectales | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Dieta | * |
dc.subject.decs | Grupo de Ascendencia Continental Europea | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Cooperación del Paciente | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Estudios Prospectivos | * |
dc.subject.decs | Estilo de Vida | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Anciano de 80 o más Años | * |
dc.subject.decs | Adulto | * |
dc.identifier.scopus | 2-s2.0-84939583778 | |
dc.identifier.wos | 354017500001 | |
dc.identifier.pui | L604272605 |
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