Recent Submissions

Characterisation of exposure to non-ionising electromagnetic fields in the Spanish INMA birth cohort: study protocol 

Background: Analysis of the association between exposure to electromagnetic fields of non-ionising radiation (EMF-NIR) and health in children and adolescents is hindered by the limited availability of data, mainly due to the difficulties on the exposure assessment. This study protocol describes the...

Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries 

Objective: To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain. Methods: Cases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for t...

Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study 

Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance wi...

Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study 

Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of ...

La Comisión Interministerial de Biomonitorización Humana en España: un reto hecho realidad 

La Comisión Interministerial de Biomonitorización Humana (CIBMH) emana del Plan Estratégico de Salud y Medio Ambiente (PESMA), como una herramienta para la implementación de la biomonitorización humana (BMH) a nivel nacional, asegurando su integración con las estrategias europeas. La BMH tiene como...

Ratio índice/anular (proxy de exposición hormonal intraútero) y riesgo de cáncer de próstata (MCC-Spain) 

Antecedentes/Objetivos: La hipótesis de la programación fetal plantea que las exposiciones durante el periodo prenatal afectan la salud del adulto. En esta línea, la exposición hormonal intrauterina (EHI) podría relacionarse con el riesgo de cáncer de próstata (CP). Un marcador propuesto para estud...

Biomarkers for personalized prevention in cancer: a rapid scoping review within the prophet project 

Background/Objectives: In the PeRsOnalized Prevention roadmap for the future HEalThcare (PROPHET) project, we assessed through a scoping review whether there is any biomarker or combination of biomarkers useful for personalized prevention -primary/secondaryof cancer. Methods: We performed a rapid s...

Neurodegenerative diseases: a rapid scoping review of biomarkers for personalized prevention 

Background/Objectives: One of the first steps of the PeRsOnalized Prevention roadmap for the future HEalThcare (PROPHET) project is to carry out several scoping reviews about research on biomarkers useful for personalized prevention -primary/secondary- of neurodegenerative diseases. Methods: A rapi...

How to stem the tide? Development of three scoping reviews in biomarkers and personalized prevention 

The “PeRsOnalized Prevention roadmap for the future HEalThcare” (PROPHET) project, seeks to assess the effectiveness, clinical utility and existing gaps in current personalized preventive approaches, and to develop a Strategy Research and Innovation Agenda (SRIA) for the European Union. The first d...

Biomarkers for personalised prevention of chronic diseases: a common protocol for three rapid scoping reviews 

Introduction: Personalised prevention aims to delay or avoid disease occurrence, progression, and recurrence of disease through the adoption of targeted interventions that consider the individual biological, including genetic data, environmental and behavioural characteristics, as well as the socio...

Interactive Gap Maps on Available Biomarkers for Risk Prediction and Stratification in Cancer, Cardiovascular, and Neurodegenerative Diseases (PROPHET Project) 

[EN] The PROPHET project (“PeRsOnalized Prevention roadmap for the future HEalThcare”), funded by the European Union's Horizon Europe research and innovation program, aims to assess the effectiveness, clinical utility, key success factors, and gaps in personalised preventive approaches for healthca...

Inequalities in mortality from breast and gynecological cancers according to level of education: a population-based study in Spain 

Background/Objectives: Educational level is one of the classic axes of inequality in public health. The recent incorporation in Spain of this information into individual mortality data makes it possible for the first time to analyze the cancer mortality risk gradient according to educational level ...

Desigualdades en el impacto de la pandemia de Covid-19 en los registros de cáncer de REDECAN 

Antecedentes/Objetivos: La pandemia COVID-19 ha producido un fuerte impacto en la sociedad y sistema sanitario. Con el objetivo de conocer cómo ha afectado a la vigilancia del cáncer en España, la Sociedad Española de Epidemiología (SEE) y la Red Española de Registros de Cáncer (REDECAN) desarrolla...

High adherence to Western dietary pattern increases breast cancer risk (an EPIC-Spain study) 

Objective: To explore the association between three previously identified and validated dietary patterns (Western, Prudent and Mediterranean) and breast cancer risk by tumour subtype and menopausal status. Methods: Data from the Spanish cohort of the European Prospective Investigation into Cancer a...

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2 

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study...

Clinical, microbiological, and molecular characterization of pediatric invasive infections by Streptococcus pyogenes in Spain in a context of global outbreak 

In December 2022, an alert was published in the UK and other European countries reporting an unusual increase in the incidence of Streptococcus pyogenes infections. Our aim was to describe the clinical, microbiological, and molecular characteristics of group A Streptococcus invasive infections (iGA...

Exposure to residential traffic and trajectories of unhealthy ageing: results from a nationally-representative cohort of older adults 

Background: Traffic exposure has been associated with biomarkers of increased biological ageing, age-related chronic morbidities, and increased respiratory, cardiovascular, and all-cause mortality. Whether it is associated with functional impairments and unhealthy ageing trajectories is unknown. Me...

Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk. 

Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuric...

The cognitive and psychiatric subacute impairment in severe Covid-19. 

Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the exi...