Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/6654
Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study
Ibáñez-Sanz, Gemma | Díez-Villanueva, Anna | Alonso, M. Henar | Rodríguez-Moranta, Francisco | Perez-Gomez, Beatriz ISCIII | Bustamante, Mariona | Martin, Vicente | Llorca, Javier | Amiano, Pilar | Ardanaz, Eva | Tardón, Adonina | Jiménez-Moleón, Jose J. | Peiró, Rosana | Alguacil, Juan | Navarro Rivas, Carmen ISCIII | Guinó, Elisabet | Binefa, Gemma | Fernandez-Navarro, Pablo ISCIII | Espinosa, Anna | Dávila-Batista, Verónica | Molina, Antonio José | Palazuelos, Camilo | Castaño-Vinyals, Gemma | Aragones, Nuria ISCIII | Kogevinas, Manolis | Moreno, Victor | Pollan-Santamaria, Marina ISCIII
Sci Rep. 2017; 7: 43263.
Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.
Colorectal Neoplasms | Environmental Exposure | Gene Frequency | Humans | Models, Statistical | Polymorphism, Single Nucleotide | Risk Assessment | Spain
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