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dc.contributor.author | Ibáñez-Sanz, Gemma | |
dc.contributor.author | Díez-Villanueva, Anna | |
dc.contributor.author | Alonso, M. Henar | |
dc.contributor.author | Rodríguez-Moranta, Francisco | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Bustamante, Mariona | |
dc.contributor.author | Martin, Vicente | |
dc.contributor.author | Llorca, Javier | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | Tardón, Adonina | |
dc.contributor.author | Jimenez-Moleon, Jose J. | |
dc.contributor.author | Peiró, Rosana | |
dc.contributor.author | Alguacil, Juan | |
dc.contributor.author | Navarro Rivas, Carmen | |
dc.contributor.author | Guinó, Elisabet | |
dc.contributor.author | Binefa, Gemma | |
dc.contributor.author | Fernandez-Navarro, Pablo L | |
dc.contributor.author | Espinosa, Anna | |
dc.contributor.author | Dávila-Batista, Verónica | |
dc.contributor.author | Molina, Antonio José | |
dc.contributor.author | Palazuelos, Camilo | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Moreno, Victor | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.date.accessioned | 2018-11-21T10:24:01Z | |
dc.date.available | 2018-11-21T10:24:01Z | |
dc.date.issued | 2017-02-24 | |
dc.identifier.citation | Sci Rep. 2017; 7: 43263. | es_ES |
dc.identifier.issn | 2045-2322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6654 | |
dc.description.abstract | Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle. | es_ES |
dc.description.sponsorship | This work was supported by the ‘Acción Transversal del Cancer’, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III, co-founded by FEDER funds –‘a way to build Europe’ (grants PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, and PI15/00069). Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09); the Junta de Castilla y León (grant LE22A10-2); the Consejería de Salud of the Junta de Andalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (grant AP 061/10); the Recercaixa (grant 2010ACUP 00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission grants FOOD-CT-2006-036224-HIWATE; the Spanish Association Against Cancer (AECC) Scientific Foundation; the Catalan Government DURSI (grant 2014SGR647); the Fundación Caja de Ahorros de Asturias; the University of Oviedo; Societat Catalana de Digestologia; and COST action BM1206 Eucolongene. | es_ES |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Colorectal Neoplasms | es_ES |
dc.subject.mesh | Environmental Exposure | es_ES |
dc.subject.mesh | Gene Frequency | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Models, Statistical | es_ES |
dc.subject.mesh | Polymorphism, Single Nucleotide | es_ES |
dc.subject.mesh | Risk Assessment | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.title | Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-4.0 Internacional | * |
dc.identifier.pubmedID | 28233817 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.page | 43263 | es_ES |
dc.identifier.doi | 10.1038/srep43263 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación Marqués de Valdecilla | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Gobierno de la Región de Murcia (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Fundación Caja de Ahorros de Asturias | |
dc.contributor.funder | University of Oviedo (España) | |
dc.contributor.funder | Sociedad Catalana de Digestología | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | 10.1038/srep43263 | es_ES |
dc.identifier.journal | Scientific Reports | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1770 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/0533 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1359 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/00773 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01286 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01903 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/02078 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01662 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01889 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00226 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01810 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02213 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00488 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00265 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/01270 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00715 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00150 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/00613 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00069 | es_ES |
dc.rights.accessRights | open access | es_ES |