Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/6654
Título
Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study
Autor(es)
Ibáñez-Sanz, Gemma | Díez-Villanueva, Anna | Alonso, M. Henar | Rodríguez-Moranta, Francisco | Perez-Gomez, Beatriz ISCIII | Bustamante, Mariona | Martin, Vicente | Llorca, Javier | Amiano, Pilar | Ardanaz, Eva | Tardón, Adonina | Jimenez-Moleon, Jose J. | Peiró, Rosana | Alguacil, Juan | Navarro Rivas, Carmen ISCIII | Guinó, Elisabet | Binefa, Gemma | Fernandez-Navarro, Pablo L ISCIII | Espinosa, Anna | Dávila-Batista, Verónica | Molina, Antonio José | Palazuelos, Camilo | Castaño-Vinyals, Gemma | Aragones, Nuria ISCIII | Kogevinas, Manolis | Moreno, Victor | Pollan-Santamaria, Marina ISCIII
Fecha de publicación
2017-02-24
Cita
Sci Rep. 2017 Feb 24:7:43263.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.
MESH
Colorectal Neoplasms | Environmental Exposure | Gene Frequency | Humans | Models, Statistical | Polymorphism, Single Nucleotide | Risk Assessment | Spain
Descripción
Corrigendum: Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study. Sci Rep. 2017 May 17:7:46807. doi: 10.1038/srep46807. PMID: 28513606.
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > IIS > IDIPHIM - Instituto de Investigación Sanitaria Puerta de Hierro (Madrid)
- Investigación > IIS > IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)
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- Corrigendum_RiskModelColorecta ...
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