Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/16328
Title
Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)
Author(s)
Palomar-Cros, Anna | Straif, Kurt | Romaguera, Dora | Aragonés, Nuria | Castaño-Vinyals, Gemma | Martin, Vicente | Moreno, Victor | Gómez-Acebo, Inés | Guevara, Marcela | Aizpurua, Amaia | Molina-Barceló, Ana | Jiménez-Moleón, José-Juan | Tardón, Adonina | Contreras-Llanes, Manuel | Marcos-Gragera, Rafael | Huerta, José Mª | Perez-Gomez, Beatriz ISCIII | Espinosa, Ana | Hernández-Segura, Natalia | Obón-Santacana, Mireia | Alonso-Molero, Jéssica | Burgui, Rosana | Amiano, Pilar | Pinto-Carbó, Marina | Olmedo-Requena, Rocío | Fernández-Tardón, Guillermo | Santos-Sánchez, Vanessa | Fernandez de Larrea-Baz, Nerea ISCIII | Fernández-Villa, Tania | Casabonne, Delphine | Dierssen-Sotos, Trinidad | Ardanaz, Eva | Dorronsoro, Ane | Pollan-Santamaria, Marina ISCIII | Kogevinas, Manolis | Lassale, Camille
Date issued
2023-09-01
Citation
Int J Cancer. 2023 Sep 1;153(5):979-993.
Language
Inglés
Document type
research article
Abstract
Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.
Subject
MESH
Stomach Neoplasms | Diabetes Mellitus | Male | Female | Humans | Sweetening Agents | Aspartame | Spain
Online version
DOI
Collections
- Investigación > IIS > IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > ISPA - Instituto de Investigación Sanitaria del Principado de Asturias (Asturias)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
- Investigación > IIS > IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)