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dc.contributor.author | Ibáñez-Sanz, Gemma | |
dc.contributor.author | Díez-Villanueva, Anna | |
dc.contributor.author | Vilorio-Marqués, Laura | |
dc.contributor.author | Gracia, Esther | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Olmedo-Requena, Rocío | |
dc.contributor.author | Llorca, Javier | |
dc.contributor.author | Vidán, Juana | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Nos, Pilar | |
dc.contributor.author | Fernández-Tardón, Guillermo | |
dc.contributor.author | Rada, Ricardo | |
dc.contributor.author | Chirlaque, María Dolores | |
dc.contributor.author | Guinó, Elisabet | |
dc.contributor.author | Dávila-Batista, Verónica | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Mirón-Pozo, Benito | |
dc.contributor.author | Dierssen-Sotos, Trinidad | |
dc.contributor.author | Etxeberria, Jaione | |
dc.contributor.author | Molinuevo, Amaia | |
dc.contributor.author | Álvarez-Cuenllas, Begoña | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.contributor.author | Moreno, Victor | |
dc.date.accessioned | 2020-02-28T07:57:58Z | |
dc.date.available | 2020-02-28T07:57:58Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sci Rep. 2018 Feb 1;8(1):2040. | es_ES |
dc.identifier.issn | 2045-2322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9154 | |
dc.description.abstract | A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine use was 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28-0.79), but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use (OR: 0.82; 95% CI: 0.47-1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62-0.97). We have not found strong evidence of an independent preventive effect of CG on CRC in our population because the observed effects of our study could be attributed to NSAIDs concurrent use. These results merit further research due to the safety profile of these drugs. | es_ES |
dc.description.sponsorship | This work was supported by the ‘Acción Transversal del Cancer’, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III, co-founded by FEDER funds –‘a way to build Europe’ (grants PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, and PI15/00069). Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09); the Junta de Castilla y León (grant LE22A10–2); the Consejería de Salud of the Junta de Andalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (grant AP 061/10); the Recercaixa (grant 2010ACUP 00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission grants FOOD-CT-2006-036224-HIWATE; the Fundación Científica Asociación Española Contra el Cáncer (AECC); the Catalan Government DURSI (grant 2014SGR647); the Fundación Caja de Ahorros de Asturias; the University of Oviedo; Societat Catalana de Digestologia; and COST action BM1206 Eucolongene. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Aged, 80 and over | es_ES |
dc.subject.mesh | Anti-Inflammatory Agents, Non-Steroidal | es_ES |
dc.subject.mesh | Case-Control Studies | es_ES |
dc.subject.mesh | Chondroitin Sulfates | es_ES |
dc.subject.mesh | Colorectal Neoplasms | es_ES |
dc.subject.mesh | Dietary Supplements | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Glucosamine | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.title | Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 29391578 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 2040 | es_ES |
dc.identifier.doi | 10.1038/s41598-018-20349-6 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación Marqués de Valdecilla | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Gobierno de la Región de Murcia (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Government of Catalonia (España) | |
dc.contributor.funder | Fundación Cajastur | |
dc.contributor.funder | University of Oviedo (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-018-20349-6 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/ PI08/1770 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/0533 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1359 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/00773 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01286 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01903 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/02078 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01662 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01889 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00226 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01810 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02213 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/ PI12/00488 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00265 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/01270 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00715 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00150 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/00613 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00069 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/API 10/09 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/LE22A10–2 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2009-S0143 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2010ACUP 00310 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AP 061/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2014SGR647 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FOOD-CT-2006-036224-HIWATE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BM1206 | es_ES |
dc.rights.accessRights | open access | es_ES |
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Este ítem aparece en la(s) siguiente(s) colección(ones)
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IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
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IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
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IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
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Centro Nacional de Epidemiología (CNE)
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ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
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IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
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IDIPHIM - Instituto de Investigación Sanitaria Puerta de Hierro (Madrid)
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IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
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IIS La Fe - Fundación para la Investigación del Hospital Universitario La Fe (C. Valenciana)
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IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)