Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/9154
Título
Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study
Autor(es)
Ibáñez-Sanz, Gemma | Díez-Villanueva, Anna | Vilorio-Marqués, Laura | Gracia, Esther | Aragones, Nuria ISCIII | Olmedo-Requena, Rocío | Llorca, Javier | Vidán, Juana | Amiano, Pilar | Nos, Pilar | Fernández-Tardón, Guillermo | Rada, Ricardo | Chirlaque, María Dolores | Guinó, Elisabet | Dávila-Batista, Verónica | Castaño-Vinyals, Gemma | Perez-Gomez, Beatriz ISCIII | Mirón-Pozo, Benito | Dierssen-Sotos, Trinidad | Etxeberria, Jaione | Molinuevo, Amaia | Álvarez-Cuenllas, Begoña | Kogevinas, Manolis | Pollan-Santamaria, Marina ISCIII | Moreno, Victor
Fecha de publicación
2018
Cita
Sci Rep. 2018 Feb 1;8(1):2040.
Idioma
Inglés
Tipo de documento
journal article
Resumen
A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine use was 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28-0.79), but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use (OR: 0.82; 95% CI: 0.47-1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62-0.97). We have not found strong evidence of an independent preventive effect of CG on CRC in our population because the observed effects of our study could be attributed to NSAIDs concurrent use. These results merit further research due to the safety profile of these drugs.
MESH
Adult | Aged | Aged, 80 and over | Anti-Inflammatory Agents, Non-Steroidal | Case-Control Studies | Chondroitin Sulfates | Colorectal Neoplasms | Dietary Supplements | Female | Glucosamine | Humans | Male | Middle Aged
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > IIS > IDIPHIM - Instituto de Investigación Sanitaria Puerta de Hierro (Madrid)
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
- Investigación > IIS > IIS La Fe - Fundación para la Investigación del Hospital Universitario La Fe (C. Valenciana)
- Investigación > IIS > IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)