Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8559
Adherence to the Western, Prudent and Mediterranean dietary patterns and breast cancer risk: MCC-Spain study
Castello, Adela ISCIII | Boldo, Elena ISCIII | Perez-Gomez, Beatriz ISCIII | Lope, Virginia ISCIII | Altzibar, Jone M | Martín, Vicente | Castaño-Vinyals, Gemma | Guevara, Marcela | Dierssen-Sotos, Trinidad | Tardón, Adonina | Moreno, Víctor | Puig-Vives, Montserrat | Llorens-Ivorra, Cristóbal | Alguacil, Juan | Gómez-Acebo, Inés | Castilla, Jesús | Gràcia-Lavedán, Esther | Dávila-Batista, Verónica | Kogevinas, Manolis | Aragones, Nuria ISCIII | Amiano, Pilar | Pollan-Santamaria, Marina ISCIII
Maturitas. 2017 Sep;103:8-15.
OBJECTIVE: To externally validate the previously identified effect on breast cancer risk of the Western, Prudent and Mediterranean dietary patterns. STUDY DESIGN: MCC-Spain is a multicase-control study that collected epidemiological information on 1181 incident cases of female breast cancer and 1682 healthy controls from 10 Spanish provinces. Three dietary patterns derived in another Spanish case-control study were analysed in the MCC-Spain study. These patterns were termed Western (high intakes of fatty and sugary products and red and processed meat), Prudent (high intakes of low-fat dairy products, vegetables, fruits, whole grains and juices) and Mediterranean (high intake of fish, vegetables, legumes, boiled potatoes, fruits, olives, and vegetable oil, and a low intake of juices). Their association with breast cancer was assessed using logistic regression models with random province-specific intercepts considering an interaction with menopausal status. Risk according to tumour subtypes - based on oestrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors (ER+/PR+ & HER2-; HER2+; ER-/PR- & HER2-) - was evaluated with multinomial regression models. MAIN OUTCOME MEASURES: Breast cancer and histological subtype. RESULTS: Our results confirm most of the associations found in the previous case-control study. A high adherence to the Western dietary pattern seems to increase breast cancer risk in both premenopausal women (OR4thvs.1stquartile (95% CI):1.68 (1.02;2.79); OR1SD-increase (95% CI):1.19 (1.02;1.40)) and postmenopausal women (OR4thvs.1stquartile(95% CI):1.48(1.07;2.05); OR1SD-increase(95% CI): 1.14 (1.01;1.29)). While high adherence to the Prudent pattern did not show any effect on breast cancer, the Mediterranean dietary pattern seemed to be protective, but only among postmenopausal women (OR4thvs.1stquartile (95% CI): 0.72 (95% CI 0.53;0.98); p-int=0.075). There were no significant differences by tumour subtype. CONCLUSION: Dietary recommendations based on a departure from the Western dietary pattern in favour of the Mediterranean diet could reduce breast cancer risk in the general population.
Breast neoplasms | Mediterranean diet | Population attributable fraction | Prevention and control | Western diet
Adult | Aged | Aged, 80 and over | Breast Neoplasms | Case-Control Studies | Female | Humans | Logistic Models | Middle Aged | Postmenopause | Premenopause | Risk Factors | Spain | Young Adult | Diet
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