Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8550
Title
Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study
Author(s)
Solans, Marta | Castelló Pastor, Adela ISCIII | Benavente, Yolanda | Marcos-Gragera, Rafael | Amiano, Pilar | Gràcia-Lavedan, Esther | Costas, Laura | Robles, Claudia | Gonzalez-Barca, Eva | de la Banda, Esmeralda | Alonso, Esther | Aymerich, Marta | Campo, Elias | Dierssen-Sotos, Trinidad | Fernández-Tardón, Guillermo | Olmedo-Requena, Rocio ISCIII | Gimeno, Eva | Castaño-Vinyals, Gemma | Aragones, Nuria ISCIII | Kogevinas, Manolis | de Sanjose, Silvia | Pollan-Santamaria, Marina ISCIII | Casabonne, Delphine
Date issued
2018
Citation
Haematologica. 2018 Nov;103(11):1881-1888.
Language
Inglés
Document type
journal article
Abstract
Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.
MESH
Adult | Aged | Aged, 80 and over | Body Mass Index | Case-Control Studies | Diet, Mediterranean | Diet, Western | Female | Humans | Leukemia, Lymphocytic, Chronic, B-Cell | Male | Middle Aged | Sex Factors | Spain | Energy Intake
Online version
DOI
Collections
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)