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dc.contributor.author | Dierssen-Sotos, Trinidad | |
dc.contributor.author | Palazuelos-Calderón, Camilo | |
dc.contributor.author | Jimenez-Moleon, Jose J. | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Altzibar, Jone M | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Martín-Sanchez, Vicente | |
dc.contributor.author | Gómez-Acebo, Inés | |
dc.contributor.author | Guevara, Marcela | |
dc.contributor.author | Tardón, Adonina | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Moreno, Victor | |
dc.contributor.author | Molina, Antonio J | |
dc.contributor.author | Alonso-Molero, Jéssica | |
dc.contributor.author | Moreno-Iribas, Conchi | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.contributor.author | Llorca, Javier | |
dc.date.accessioned | 2019-01-30T12:58:10Z | |
dc.date.available | 2019-01-30T12:58:10Z | |
dc.date.issued | 2018-03-12 | |
dc.identifier.citation | BMC Cancer. 2018 Mar 12;18(1):280. | es_ES |
dc.identifier.issn | 1471-2407 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7022 | |
dc.description.abstract | BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect. | es_ES |
dc.description.sponsorship | This work was partially funded by the “Accion Transversal del Cancer”, approved by the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)); The Junta de Castilla y León [LE22A10–2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOOD-CT-2006-036224-HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central (BMC) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Breast cancer | es_ES |
dc.subject | Genetic interactions | es_ES |
dc.subject | Reproductive factors | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Alleles | es_ES |
dc.subject.mesh | Basic-Leucine Zipper Transcription Factors | es_ES |
dc.subject.mesh | Breast Neoplasms | es_ES |
dc.subject.mesh | Cyclic AMP Response Element-Binding Protein | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Genetic Predisposition to Disease | es_ES |
dc.subject.mesh | Hormones | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Metabolic Networks and Pathways | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Mutation | es_ES |
dc.subject.mesh | Nerve Tissue Proteins | es_ES |
dc.subject.mesh | Parity | es_ES |
dc.subject.mesh | Polymorphism, Single Nucleotide | es_ES |
dc.subject.mesh | Pregnancy | es_ES |
dc.subject.mesh | Reproduction | es_ES |
dc.subject.mesh | Ribosomal Protein S6 Kinases, 90-kDa | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Surveys and Questionnaires | es_ES |
dc.subject.mesh | src-Family Kinases | es_ES |
dc.title | Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution 4.0 International | |
dc.identifier.pubmedID | 29530003 | es_ES |
dc.format.volume | 18 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 280 | es_ES |
dc.identifier.doi | 10.1186/s12885-018-4182-3 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación Marqués de Valdecilla | |
dc.contributor.funder | International Cancer Genome Consortium | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Gobierno de la Región de Murcia (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Fundación Caja de Ahorros de Asturias | |
dc.contributor.funder | University of Oviedo (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1471-2407 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1186/s12885-018-4182-3 | es_ES |
dc.identifier.journal | BMC cancer | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1770 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/0533 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1359 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/00773-Cantabria | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01286-León | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01903-Valencia | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/02078-Huelva | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01662-Granada | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01889-FEDER | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00226 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01810 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02213 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00488 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00265 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/01270 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00715 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00150 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/0613 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00069 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00914 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/01032 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0036 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EU/FOOD-CT-2006-036224-HIWATE | es_ES |
dc.rights.accessRights | open access | es_ES |
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Este ítem aparece en la(s) siguiente(s) colección(ones)
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IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
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IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
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IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
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Centro Nacional de Epidemiología (CNE)
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ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
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IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
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IDIPHIM - Instituto de Investigación Sanitaria Puerta de Hierro (Madrid)
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IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)