Show simple item record

dc.contributor.authorDierssen-Sotos, Trinidad
dc.contributor.authorPalazuelos-Calderón, Camilo
dc.contributor.authorJimenez-Moleon, Jose J.
dc.contributor.authorAragones, Nuria 
dc.contributor.authorAltzibar, Jone M
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorMartín-Sanchez, Vicente
dc.contributor.authorGómez-Acebo, Inés
dc.contributor.authorGuevara, Marcela
dc.contributor.authorTardón, Adonina
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorAmiano, Pilar
dc.contributor.authorMoreno, Victor
dc.contributor.authorMolina, Antonio J
dc.contributor.authorAlonso-Molero, Jéssica
dc.contributor.authorMoreno-Iribas, Conchi
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorLlorca, Javier
dc.date.accessioned2019-01-30T12:58:10Z
dc.date.available2019-01-30T12:58:10Z
dc.date.issued2018-03-12
dc.identifier.citationBMC Cancer. 2018 Mar 12;18(1):280.es_ES
dc.identifier.issn1471-2407es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7022
dc.description.abstractBACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.es_ES
dc.description.sponsorshipThis work was partially funded by the “Accion Transversal del Cancer”, approved by the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)); The Junta de Castilla y León [LE22A10–2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOOD-CT-2006-036224-HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBreast canceres_ES
dc.subjectGenetic interactionses_ES
dc.subjectReproductive factorses_ES
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshAlleles es_ES
dc.subject.meshBasic-Leucine Zipper Transcription Factors es_ES
dc.subject.meshBreast Neoplasms es_ES
dc.subject.meshCyclic AMP Response Element-Binding Protein es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGenetic Predisposition to Disease es_ES
dc.subject.meshHormones es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMetabolic Networks and Pathways es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshMutation es_ES
dc.subject.meshNerve Tissue Proteins es_ES
dc.subject.meshParity es_ES
dc.subject.meshPolymorphism, Single Nucleotide es_ES
dc.subject.meshPregnancy es_ES
dc.subject.meshReproduction es_ES
dc.subject.meshRibosomal Protein S6 Kinases, 90-kDa es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSpain es_ES
dc.subject.meshSurveys and Questionnaires es_ES
dc.subject.meshsrc-Family Kinases es_ES
dc.titleReproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain projectes_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution 4.0 International
dc.identifier.pubmedID29530003es_ES
dc.format.volume18es_ES
dc.format.number1es_ES
dc.format.page280es_ES
dc.identifier.doi10.1186/s12885-018-4182-3es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderFundación Marqués de Valdecilla 
dc.contributor.funderInternational Cancer Genome Consortium 
dc.contributor.funderJunta de Castilla y León (España) 
dc.contributor.funderRegional Government of Andalusia (España) 
dc.contributor.funderGeneralitat Valenciana (España) 
dc.contributor.funderFundación La Caixa 
dc.contributor.funderBasque Government (España) 
dc.contributor.funderGobierno de la Región de Murcia (España) 
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.contributor.funderFundación Caja de Ahorros de Asturias 
dc.contributor.funderUniversity of Oviedo (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1471-2407es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/s12885-018-4182-3es_ES
dc.identifier.journalBMC canceres_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0533es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1359es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/00773-Cantabriaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/01286-Leónes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/01903-Valenciaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/02078-Huelvaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/01662-Granadaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01403es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01889-FEDERes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/00226es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01810es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02213es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/01270es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00150es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/01219es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/0613es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00069es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00914es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/01032es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0036/0036es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/FOOD-CT-2006-036224-HIWATEes_ES
dc.rights.accessRightsopen accesses_ES


Files in this item

Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
This item is licensed under a: Attribution 4.0 International