Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7022
Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
Dierssen-Sotos, Trinidad | Palazuelos-Calderón, Camilo | Jiménez-Moleón, José-Juan | Aragones, Nuria ISCIII | Altzibar, Jone M | Castaño-Vinyals, Gemma | Martín-Sanchez, Vicente | Gómez-Acebo, Inés | Guevara, Marcela | Tardón, Adonina | Perez-Gomez, Beatriz ISCIII | Amiano, Pilar | Moreno, Victor | Molina, Antonio J | Alonso-Molero, Jéssica | Moreno-Iribas, Conchi | Kogevinas, Manolis | Pollan-Santamaria, Marina ISCIII | Llorca, Javier
BMC Cancer. 2018 Mar 12;18(1):280.
BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
Adult | Aged | Alleles | Basic-Leucine Zipper Transcription Factors | Breast Neoplasms | Cyclic AMP Response Element-Binding Protein | Female | Genetic Predisposition to Disease | Hormones | Humans | Metabolic Networks and Pathways | Middle Aged | Mutation | Nerve Tissue Proteins | Parity | Polymorphism, Single Nucleotide | Pregnancy | Reproduction | Ribosomal Protein S6 Kinases, 90-kDa | Risk Factors | Spain | Surveys and Questionnaires | src-Family Kinases
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