Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7022
Título
Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
Autor(es)
Dierssen-Sotos, Trinidad | Palazuelos-Calderón, Camilo | Jimenez-Moleon, Jose J. | Aragones, Nuria ISCIII | Altzibar, Jone M | Castaño-Vinyals, Gemma | Martín-Sanchez, Vicente | Gómez-Acebo, Inés | Guevara, Marcela | Tardón, Adonina | Perez-Gomez, Beatriz ISCIII | Amiano, Pilar | Moreno, Victor | Molina, Antonio J | Alonso-Molero, Jéssica | Moreno-Iribas, Conchi | Kogevinas, Manolis | Pollan-Santamaria, Marina ISCIII | Llorca, Javier
Fecha de publicación
2018-03-12
Cita
BMC Cancer. 2018 Mar 12;18(1):280.
Idioma
Inglés
Tipo de documento
journal article
Resumen
BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
Palabras clave
MESH
Adult | Aged | Alleles | Basic-Leucine Zipper Transcription Factors | Breast Neoplasms | Cyclic AMP Response Element-Binding Protein | Female | Genetic Predisposition to Disease | Hormones | Humans | Metabolic Networks and Pathways | Middle Aged | Mutation | Nerve Tissue Proteins | Parity | Polymorphism, Single Nucleotide | Pregnancy | Reproduction | Ribosomal Protein S6 Kinases, 90-kDa | Risk Factors | Spain | Surveys and Questionnaires | src-Family Kinases
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > IIS > IDIPHIM - Instituto de Investigación Sanitaria Puerta de Hierro (Madrid)
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)