Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/15825
Title
Toenail zinc as a biomarker: Relationship with sources of environmental exposure and with genetic variability in MCC-Spain study
Author(s)
Gutiérrez-González, Enrique | Fernandez-Navarro, Pablo L ISCIII | Pastor-Barriuso, Roberto ISCIII | García-Pérez, Javier ISCIII | Castaño-Vinyals, Gemma | Martín-Sánchez, Vicente | Amiano, Pilar | Gómez-Acebo, Inés | Guevara, Marcela | Fernández-Tardón, Guillermo | Salcedo-Bellido, Inmaculada | Moreno, Victor | Pinto-Carbó, Marina | Alguacil, Juan | Marcos-Gragera, Rafael | Gómez-Gómez, Jesús Humberto | Gómez-Ariza, José Luis | García-Barrera, Tamara | Varea-Jiménez, Elena ISCIII | Nuñez, Olivier ISCIII | Espinosa, Ana | Molina de la Torre, Antonio J | Aizpurua-Atxega, Amaia | Alonso-Molero, Jéssica | Ederra-Sanz, María | Belmonte, Thalia | Aragonés, Nuria | Kogevinas, Manolis | Pollan-Santamaria, Marina ISCIII | Perez-Gomez, Beatriz ISCIII
Date issued
2022-11
Citation
Environ Int. 2022 Nov;169:107525.
Language
Inglés
Document type
journal article
Abstract
Background: Toenails are commonly used as biomarkers of exposure to zinc (Zn), but there is scarce information about their relationship with sources of exposure to Zn. Objectives: To investigate the main determinants of toenail Zn, including selected sources of environmental exposure to Zn and individual genetic variability in Zn metabolism. Methods: We determined toenail Zn by inductively coupled plasma mass spectrometry in 3,448 general population controls from the MultiCase-Control study MCC-Spain. We assessed dietary and supplement Zn intake using food frequency questionnaires, residential proximity to Zn-emitting industries and residential topsoil Zn levels through interpolation methods. We constructed a polygenic score of genetic variability based on 81 single nucleotide polymorphisms in genes involved in Zn metabolism. Geometric mean ratios of toenail Zn across categories of each determinant were estimated from multivariate linear regression models on log-transformed toenail Zn. Results: Geometric mean toenail Zn was 104.1 µg/g in men and 100.3 µg/g in women. Geometric mean toenail Zn levels were 7 % lower (95 % confidence interval 1-13 %) in men older than 69 years and those in the upper tertile of fibre intake, and 9 % higher (3-16 %) in smoking men. Women residing within 3 km from Zn-emitting industries had 4 % higher geometric mean toenail Zn levels (0-9 %). Dietary Zn intake and polygenic score were unrelated to toenail Zn. Overall, the available determinants only explained 9.3 % of toenail Zn variability in men and 4.8 % in women. Discussion: Sociodemographic factors, lifestyle, diet, and environmental exposure explained little of the individual variability of toenail Zn in the study population. The available genetic variants related to Zn metabolism were not associated with toenail Zn.
Subject
Toenail | Environmental exposure | Biomarker | Zinc | Single nucleotide polymorphism | Polygenic score
MESH
Nails | Zinc | Biomarkers | Environmental Exposure | Female | Humans | Male | Organic Chemicals | Soil | Spain
Online version
DOI
Collections
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > ISPA - Instituto de Investigación Sanitaria del Principado de Asturias (Asturias)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > IIS > IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)
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