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dc.contributor.author | Gutiérrez-González, Enrique | |
dc.contributor.author | Fernandez-Navarro, Pablo L | |
dc.contributor.author | Pastor-Barriuso, Roberto | |
dc.contributor.author | García-Pérez, Javier | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Martín-Sánchez, Vicente | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Gómez-Acebo, Inés | |
dc.contributor.author | Guevara, Marcela | |
dc.contributor.author | Fernández-Tardón, Guillermo | |
dc.contributor.author | Salcedo-Bellido, Inmaculada | |
dc.contributor.author | Moreno, Victor | |
dc.contributor.author | Pinto-Carbó, Marina | |
dc.contributor.author | Alguacil, Juan | |
dc.contributor.author | Marcos-Gragera, Rafael | |
dc.contributor.author | Gómez-Gómez, Jesús Humberto | |
dc.contributor.author | Gómez-Ariza, José Luis | |
dc.contributor.author | García-Barrera, Tamara | |
dc.contributor.author | Varea-Jiménez, Elena | |
dc.contributor.author | Nuñez, Olivier | |
dc.contributor.author | Espinosa, Ana | |
dc.contributor.author | Molina de la Torre, Antonio J | |
dc.contributor.author | Aizpurua-Atxega, Amaia | |
dc.contributor.author | Alonso-Molero, Jéssica | |
dc.contributor.author | Ederra-Sanz, María | |
dc.contributor.author | Belmonte, Thalia | |
dc.contributor.author | Aragonés, Nuria | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.date.accessioned | 2023-04-17T11:07:30Z | |
dc.date.available | 2023-04-17T11:07:30Z | |
dc.date.issued | 2022-11 | |
dc.identifier.citation | Environ Int. 2022 Nov;169:107525. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15825 | |
dc.description.abstract | Background: Toenails are commonly used as biomarkers of exposure to zinc (Zn), but there is scarce information about their relationship with sources of exposure to Zn. Objectives: To investigate the main determinants of toenail Zn, including selected sources of environmental exposure to Zn and individual genetic variability in Zn metabolism. Methods: We determined toenail Zn by inductively coupled plasma mass spectrometry in 3,448 general population controls from the MultiCase-Control study MCC-Spain. We assessed dietary and supplement Zn intake using food frequency questionnaires, residential proximity to Zn-emitting industries and residential topsoil Zn levels through interpolation methods. We constructed a polygenic score of genetic variability based on 81 single nucleotide polymorphisms in genes involved in Zn metabolism. Geometric mean ratios of toenail Zn across categories of each determinant were estimated from multivariate linear regression models on log-transformed toenail Zn. Results: Geometric mean toenail Zn was 104.1 µg/g in men and 100.3 µg/g in women. Geometric mean toenail Zn levels were 7 % lower (95 % confidence interval 1-13 %) in men older than 69 years and those in the upper tertile of fibre intake, and 9 % higher (3-16 %) in smoking men. Women residing within 3 km from Zn-emitting industries had 4 % higher geometric mean toenail Zn levels (0-9 %). Dietary Zn intake and polygenic score were unrelated to toenail Zn. Overall, the available determinants only explained 9.3 % of toenail Zn variability in men and 4.8 % in women. Discussion: Sociodemographic factors, lifestyle, diet, and environmental exposure explained little of the individual variability of toenail Zn in the study population. The available genetic variants related to Zn metabolism were not associated with toenail Zn. | es_ES |
dc.description.sponsorship | The study was supported by the “Acción Transversal del Cáncer”, approved on the Spanish Ministry Council on the 11 October 2007, by the Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), by the Instituto de Salud Carlos III grants, co-funded by FEDER funds -a way to build Europe- PI08/1770, PI09/0773, PI12/00715, PI09/1903, PI09/2078; PI09/1662; PI11/01403; PI12/00150; PI12/00488; PI15/00914; PI17CIII_00034; by the Fundación Marqués de Valdecilla grant API 10/09, by the Consejería de Salud of the Junta de Andalucía grant 2009-S0143, by the Conselleria de Sanitat of the Generalitat Valenciana grant AP061/10, by the Regional Government of the Basque Country, by the Fundación Caja de Ahorros de Asturias, by the University of Oviedo and by the Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporación grant IJCI-2014-20900. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Toenail | es_ES |
dc.subject | Environmental exposure | es_ES |
dc.subject | Biomarker | es_ES |
dc.subject | Zinc | es_ES |
dc.subject | Single nucleotide polymorphism | es_ES |
dc.subject | Polygenic score | es_ES |
dc.subject.mesh | Nails | es_ES |
dc.subject.mesh | Zinc | es_ES |
dc.subject.mesh | Biomarkers | es_ES |
dc.subject.mesh | Environmental Exposure | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Organic Chemicals | es_ES |
dc.subject.mesh | Soil | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.title | Toenail zinc as a biomarker: Relationship with sources of environmental exposure and with genetic variability in MCC-Spain study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 36150295 | es_ES |
dc.format.volume | 169 | es_ES |
dc.format.page | 107525 | es_ES |
dc.identifier.doi | 10.1016/j.envint.2022.107525 | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Fundación Marqués de Valdecilla | es_ES |
dc.contributor.funder | Regional Government of Andalusia (España) | es_ES |
dc.contributor.funder | Generalitat Valenciana (España) | es_ES |
dc.contributor.funder | Basque Government (España) | es_ES |
dc.contributor.funder | Fundación Caja de Ahorros de Asturias | es_ES |
dc.contributor.funder | University of Oviedo (España) | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1873-6750 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.envint.2022.107525 | es_ES |
dc.identifier.journal | Environment international | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//IJCI-2014-20900/ES/IJCI-2014-20900/ | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI08/1770 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI09/0773 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2012) (2012)/PI12/00715 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI09/1903 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI09/2078 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI09/1662 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2011) (2011)/PI11/01403 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2012) (2012)/PI12/00150 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2012) (2012)/PI12/00488 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2015). Modalidad proyectos en salud. (2015)/PI15/00914 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI17CIII_00034 | es_ES |
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Este ítem aparece en la(s) siguiente(s) colección(ones)
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IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
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ISPA - Instituto de Investigación Sanitaria del Principado de Asturias (Asturias)
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IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
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IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
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Centro Nacional de Epidemiología (CNE)
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IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
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IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)