Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/14207
Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study
Papantoniou, Kyriaki | Castaño-Vinyals, Gemma | Espinosa, Ana | Turner, Michelle C | Martín-Sánchez, Vicente | Casabonne, Delphine | Aragonés, Nuria | Gómez-Acebo, Inés | Ardanaz, Eva | Jimenez-Moleon, Jose-Juan | Amiano, Pilar | Molina-Barceló, Ana | Alguacil, Juan | Fernández-Tardón, Guillermo | Huerta, José María | Hernández-Segura, Natalia | Perez-Gomez, Beatriz ISCIII | Llorca, Javier | Vidán-Alli, Juana | Olmedo-Requena, Rocıo | Gil, Leire | Castañon-López, Carmen | Pollan-Santamaria, Marina ISCIII | Kogevinas, Manolis | Moreno, Victor
Sci Rep. 2021;11(1):11822.
Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.
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