Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13873
Título
Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study
Autor(es)
Solans, Marta | Fernández-Barrés, Sílvia | Romaguera, Dora | Benavente, Yolanda | Marcos-Gragera, Rafael | Gràcia-Lavedan, Esther | Costas, Laura | Robles, Claudia | Gonzalez-Barca, Eva | de la Banda, Esmeralda | Alonso, Esther | Aymerich, Marta | Campo, Elias | Llorca, Javier | Fernández-Tardón, Guillermo | Olmedo-Requena, Rocío | Gimeno, Eva | Castaño-Vinyals, Gemma | Aragonés, Nuria | Kogevinas, Manolis | Pollan-Santamaria, Marina ISCIII | de Sanjose, Silvia | Amiano, Pilar | Casabonne, Delphine
Fecha de publicación
2021-05-20
Cita
Int J Environ Res Public Health. 2021 May 20;18(10):5457.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within <1 year (incident), each 10% increment in the consumption of UPF was associated with a 22% higher odds ratio of CLL (95% CI: 1.02, 1.47) suggesting that the overall results might be affected by the inclusion of prevalent cases, who might have changed their dietary habits after cancer diagnosis. Given the low number of cases in the subgroup analyses and multiple tests performed, chance findings cannot totally be ruled out. Nonetheless, positive associations found in CLL incident cases merit further research, ideally in well-powered studies with a prospective design.
Palabras clave
NOVA classification | Cancer | Case-control study | Chronic lymphocytic leukemia | Ultra-processed food
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > ISPA - Instituto de Investigación Sanitaria del Principado de Asturias (Asturias)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
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