2024-03-28T22:04:52Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/138732024-02-01T12:03:48Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16990col_20.500.12105_16983col_20.500.12105_16974col_20.500.12105_16970col_20.500.12105_16967col_20.500.12105_16962col_20.500.12105_16959col_20.500.12105_2054
Repisalud
author
Solans, Marta
author
Fernández-Barrés, Sílvia
author
Romaguera, Dora
author
Benavente, Yolanda
author
Marcos-Gragera, Rafael
author
Gràcia-Lavedan, Esther
author
Costas, Laura
author
Robles, Claudia
author
Gonzalez-Barca, Eva
author
de la Banda, Esmeralda
author
Alonso, Esther
author
Aymerich, Marta
author
Campo, Elias
author
Llorca, Javier
author
Fernández-Tardón, Guillermo
author
Olmedo-Requena, Rocío
author
Gimeno, Eva
author
Castaño-Vinyals, Gemma
author
Aragonés, Nuria
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
de Sanjose, Silvia
author
Amiano, Pilar
author
Casabonne, Delphine
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
funder
Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)
funder
Institució Catalana de Recerca i Estudis Avançats
2022-03-29T09:13:54Z
2022-03-29T09:13:54Z
2021-05-20
Int J Environ Res Public Health. 2021 May 20;18(10):5457.
http://hdl.handle.net/20.500.12105/13873
34065213
10.3390/ijerph18105457
1660-4601
International Journal of Environmental Research and Public Health
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within <1 year (incident), each 10% increment in the consumption of UPF was associated with a 22% higher odds ratio of CLL (95% CI: 1.02, 1.47) suggesting that the overall results might be affected by the inclusion of prevalent cases, who might have changed their dietary habits after cancer diagnosis. Given the low number of cases in the subgroup analyses and multiple tests performed, chance findings cannot totally be ruled out. Nonetheless, positive associations found in CLL incident cases merit further research, ideally in well-powered studies with a prospective design.
eng
NOVA classification
Cancer
Case-control study
Chronic lymphocytic leukemia
Ultra-processed food
Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/13873/1/ConsumptionOfUltraProcessed_2021.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/13873/2/ConsumptionOfUltraProcessedSupplementaryMaterials_2021.pdf
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ConsumptionOfUltraProcessed_2021.pdf.txt
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https://repisalud.isciii.es/bitstream/20.500.12105/13873/7/ConsumptionOfUltraProcessedSupplementaryMaterials_2021.pdf.txt
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