dc.contributor.author | Vallès, Xavier | |
dc.contributor.author | Alonso, M Henar | |
dc.contributor.author | López-Caleya, Juan Francisco | |
dc.contributor.author | Díez-Obrero, Virginia | |
dc.contributor.author | Dierssen-Sotos, Trinidad | |
dc.contributor.author | Lope Carvajal, Virginia | |
dc.contributor.author | Molina-Barceló, Ana | |
dc.contributor.author | Chirlaque, María Dolores | |
dc.contributor.author | Jimenez-Moleon, Jose J. | |
dc.contributor.author | Fernández Tardón, Guillermo | |
dc.contributor.author | Castilla Catalán, Jesús | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Capelo, Rocío | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Guinó, Elisabet | |
dc.contributor.author | Molina de la Torre, Antonio José | |
dc.contributor.author | Moreno-Iribas, Conchi | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Llorca, Javier | |
dc.contributor.author | Martín, Vicente | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.contributor.author | Moreno, Victor | |
dc.date.accessioned | 2020-01-29T11:22:37Z | |
dc.date.available | 2020-01-29T11:22:37Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Environ Int. 2018 Dec;121(Pt 1):428-434. | es_ES |
dc.identifier.issn | 0160-4120 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8935 | |
dc.description.abstract | OBJECTIVES: To explore the association of colorectal cancer with environmental solar radiation and sun exposure behavior, considering phenotypic variables (eye color, hair color and skin phenotype), dietary intake of vitamin D and calcium, and socio-demographic factors. STUDY DESIGN: Multicenter population-based frequency matched case-control study in Spain (MCC-Spain), with 2140 CRC cases and 3950 controls. METHODS: Data were obtained through personal interviews using a structured epidemiological questionnaire that included socio-demographic data, residential history, environmental exposures, behavior, phenotypic and dietary information. An environmental-lifetime sun exposure score was constructed combining residential history and average daily solar radiation, direct and diffuse. Logistic regression was used to explore the association between different variables. A structural equation model was used to verify the associations of the conceptual model. RESULTS: We found a lower risk of CRC in subjects frequently exposed to sunlight during the previous summer and skin burning due to sun exposure. No association was observed in relation to the residential solar radiation scores. Subjects with light eye or light hair colors had a lower risk of CRC that those with darker colors. Dietary calcium and vitamin D were also protective factors, but not in the multivariate model. The structural equation model analysis suggested that higher sun exposure was associated with a decreased risk of CRC, as well as dietary intake of calcium and vitamin D, and these factors are correlated among themselves and with environmental solar radiation and skin phenotypes. CONCLUSION: The results agree with previous observations that sun exposure, dietary vitamin D and calcium intake, and serum 25(OH)D concentration reduce the risk of CRC and indicate that these factors may be relevant for cancer prevention. | es_ES |
dc.description.sponsorship | The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER, a way to build Europe (PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Consejería de Educación, Junta de Castilla y León (LE22A10-2), by the Consejería de Salud, Junta de Andalucía (2009-S0143), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad y Política Social, Comunidad Autónoma de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Scientific Foundation, Spanish Association Against Cancer (AECC), by the Agency for Management of University and Research Grants (AGAUR) of the Catalan Government grant 2017SGR723, by the Fundación Bancaria Caja de Ahorros de Asturias and by the University of Oviedo.
Samples: Biological samples were stored at the biobanks supported by Instituto de Salud Carlos III-FEDER: Parc de Salut MAR Biobank (MARBiobanc) (RD09/0076/00036), “Biobanco La Fe” (RD 09 0076/00021) and FISABIO Biobank (RD09 0076/00058). Also at the Public Health Laboratory from Gipuzkoa, the Basque Biobank, the ICOBIOBANC PT13/0010/0013 (sponsored by the Catalan Institute of Oncology), the IUOPA Biobank from the University of Oviedo and the ISCIII Biobank. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Calcium | es_ES |
dc.subject | Colorectal cancer | es_ES |
dc.subject | Skin phenotype | es_ES |
dc.subject | Sunlight | es_ES |
dc.subject | Vitamin D | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Aged, 80 and over | es_ES |
dc.subject.mesh | Calcium, Dietary | es_ES |
dc.subject.mesh | Case-Control Studies | es_ES |
dc.subject.mesh | Colorectal Neoplasms | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Incidence | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Protective Agents | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Vitamin D | es_ES |
dc.subject.mesh | Vitamins | es_ES |
dc.subject.mesh | Young Adult | es_ES |
dc.subject.mesh | Sunlight | es_ES |
dc.title | Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivs 4.0 International | * |
dc.identifier.pubmedID | 30266013 | es_ES |
dc.format.volume | 121 | es_ES |
dc.format.number | Pt 1 | es_ES |
dc.format.page | 428-434 | es_ES |
dc.identifier.doi | 10.1016/j.envint.2018.09.030 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | International Cancer Genome Consortium | |
dc.contributor.funder | Fundación Marqués de Valdecilla | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Gobierno de la Región de Murcia (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) | |
dc.contributor.funder | Fundación Caja de Ahorros de Asturias | |
dc.contributor.funder | University of Oviedo (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1873-6750 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.envint.2018.09.030 | es_ES |
dc.identifier.journal | Environment international | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1770 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/0533 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1359 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/00773-Cantabria | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01286-León | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01903-Valencia | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/02078-Huelva | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01662-Granada | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01889-FEDER | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00226 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01810 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02213 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00488 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00265 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/01270 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00715 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00150 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/0613 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/API 10/09 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0036 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/LE22A10-2 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2009-S0143 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AP_061/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2010ACUP 00310 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FOOD-CT-2006-036224-HIWATE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2017SGR723 | es_ES |
dc.rights.accessRights | open access | es_ES |