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dc.contributor.authorAlonso-Molero, Jessica
dc.contributor.authorMolina, Antonio J
dc.contributor.authorJiménez-Moleón, Jose Juan
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorMartin, Vicente
dc.contributor.authorMoreno, Victor
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorde Sanjose, Silvia
dc.contributor.authorSalcedo, Inmaculada
dc.contributor.authorFernandez-Tardon, Guillermo
dc.contributor.authorAlguacil, Juan
dc.contributor.authorSalas, Dolores
dc.contributor.authorMarcos-Gragera, Rafael
dc.contributor.authorChirlaque, Maria Dolores
dc.contributor.authorAragones, Nuria 
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorLlorca, Javier
dc.date.accessioned2019-12-03T13:38:56Z
dc.date.available2019-12-03T13:38:56Z
dc.date.issued2019-11-21
dc.identifier.citationBMJ Open. 2019 Nov 21;9(11):e031904.es_ES
dc.identifier.issn2044-6055es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8737
dc.description.abstractPURPOSE: Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate cancers were assembled using the incident cases originally recruited. PARTICIPANTS: 2140 new cases of colorectal cancer, 1732 of breast cancer and 1112 of prostate cancer were initially recruited in 12 Spanish provinces; all cancers were incident and pathologically confirmed. Follow-up was obtained for 2097 (98%), 1685 (97%) and 1055 (94.9%) patients, respectively. FINDINGS TO DATE: Information gathered at recruitment included sociodemographic factors, medical history, lifestyle and environmental exposures. Biological samples were obtained, and 80% of patients were genotyped using a commercial exome array. The follow-up was performed by (1) reviewing medical records; (2) interviewing the patients by phone on quality of life; and (3) verifying vital status and cause of death in the Spanish National Death Index. Ninety-seven per cent of recruited patients were successfully followed up in 2017 or 2018; patient-years of follow-up were 30 914. Most colorectal cancers (52%) were at clinical stage II or lower at recruitment; 819 patients died in the follow-up and the 5-year survival was better for women (74.4%) than men (70.0%). 71% of breast cancers were diagnosed at stages I or II; 206 women with breast cancer died in the follow-up and the 5-year survival was 90.7%. 49% of prostate cancers were diagnosed at stage II and 32% at stage III; 119 patients with prostate cancer died in the follow-up and the 5-year survival was 93.7%. FUTURE PLANS: MCC-Spain has built three prospective cohorts on highly frequent cancers across Spain, allowing to investigate socioeconomic, clinical, lifestyle, environmental and genetic variables as putative prognosis factors determining survival of patients of the three cancers and the inter-relationship of these factors.es_ES
dc.description.sponsorshipFunding The study was partially funded by the 'Accion Transversal del Cancer', approved on the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034, PI18/00181), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (the ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission (grants FOOD-CT-2006-036224-HIWATE), by the Spanish Association Against Cancer (AECC) Scientific Foundation (GCTRA18022MORE), by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) (grants 2017SGR723 and 2014SGR850), by the Fundación Caja de Ahorros de Asturias, and by the University of Oviedo. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.es_ES
dc.language.isoenges_ES
dc.publisherBMJ Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectMCC-Spaines_ES
dc.subjectbreast canceres_ES
dc.subjectcohortes_ES
dc.subjectcolorectal canceres_ES
dc.subjectepidemiologyes_ES
dc.subjectprostate canceres_ES
dc.titleCohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial resultses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID31753885es_ES
dc.format.volume9es_ES
dc.format.number11es_ES
dc.format.pagee031904es_ES
dc.identifier.doi10.1136/bmjopen-2019-031904es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderFundación Marqués de Valdecillaes_ES
dc.contributor.funderInternational Cancer Genome Consortium CLLes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderRed Temática de Investigación Cooperativa en Cáncer (España)es_ES
dc.contributor.funderJunta de Castilla y Leónes_ES
dc.contributor.funderGobierno de Andalucíaes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderRecercaixaes_ES
dc.contributor.funderGobierno Vascoes_ES
dc.contributor.funderGobierno de Murciaes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderFundación Científica AECCes_ES
dc.contributor.funderFundación Caja de Ahorros de Asturiases_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2044-6055es_ES
dc.relation.publisherversionhttps://doi.org/10.1136/bmjopen-2019-031904es_ES
dc.identifier.journalBMJ openes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemología::Área de Epidemiología Ambiental y Cánceres_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0533es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1359es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/00773es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01286-Leónes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01903-Valenciaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/02078-Huelvaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01662-Granadaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01403es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01889-FEDERes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/00226es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01810es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02213es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/01270es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00150es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/01219es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/0613es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00069es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00914es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/01032es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17CIII/00034es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18/00181es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/API 10/09es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0036/0036es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/LE22A10-2es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI-0571-2009es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI-0306-2011es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/salud201200057018traes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AP_061/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2010ACUP 00310es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/grants FOOD-CT-2006-036224-HIWATEes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/grants 2017SGR723es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/GCTRA18022MOREes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2014SGR850es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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