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dc.contributor.author | Alonso-Molero, Jéssica | |
dc.contributor.author | Molina, Antonio J | |
dc.contributor.author | Jimenez-Moleon, Jose J. | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Martin, Vicente | |
dc.contributor.author | Moreno, Victor | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | de Sanjose, Silvia | |
dc.contributor.author | Salcedo, Inmaculada | |
dc.contributor.author | Fernández-Tardón, Guillermo | |
dc.contributor.author | Alguacil, Juan | |
dc.contributor.author | Salas, Dolores | |
dc.contributor.author | Marcos-Gragera, Rafael | |
dc.contributor.author | Chirlaque, Maria Dolores | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Llorca, Javier | |
dc.date.accessioned | 2019-12-03T13:38:56Z | |
dc.date.available | 2019-12-03T13:38:56Z | |
dc.date.issued | 2019-11-21 | |
dc.identifier.citation | BMJ Open. 2019 Nov 21;9(11):e031904. | es_ES |
dc.identifier.issn | 2044-6055 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8737 | |
dc.description.abstract | PURPOSE: Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate cancers were assembled using the incident cases originally recruited. PARTICIPANTS: 2140 new cases of colorectal cancer, 1732 of breast cancer and 1112 of prostate cancer were initially recruited in 12 Spanish provinces; all cancers were incident and pathologically confirmed. Follow-up was obtained for 2097 (98%), 1685 (97%) and 1055 (94.9%) patients, respectively. FINDINGS TO DATE: Information gathered at recruitment included sociodemographic factors, medical history, lifestyle and environmental exposures. Biological samples were obtained, and 80% of patients were genotyped using a commercial exome array. The follow-up was performed by (1) reviewing medical records; (2) interviewing the patients by phone on quality of life; and (3) verifying vital status and cause of death in the Spanish National Death Index. Ninety-seven per cent of recruited patients were successfully followed up in 2017 or 2018; patient-years of follow-up were 30 914. Most colorectal cancers (52%) were at clinical stage II or lower at recruitment; 819 patients died in the follow-up and the 5-year survival was better for women (74.4%) than men (70.0%). 71% of breast cancers were diagnosed at stages I or II; 206 women with breast cancer died in the follow-up and the 5-year survival was 90.7%. 49% of prostate cancers were diagnosed at stage II and 32% at stage III; 119 patients with prostate cancer died in the follow-up and the 5-year survival was 93.7%. FUTURE PLANS: MCC-Spain has built three prospective cohorts on highly frequent cancers across Spain, allowing to investigate socioeconomic, clinical, lifestyle, environmental and genetic variables as putative prognosis factors determining survival of patients of the three cancers and the inter-relationship of these factors. | es_ES |
dc.description.sponsorship | Funding The study was partially funded by the 'Accion Transversal del Cancer', approved on the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034, PI18/00181), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (the ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission (grants FOOD-CT-2006-036224-HIWATE), by the Spanish Association Against Cancer (AECC) Scientific Foundation (GCTRA18022MORE), by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) (grants 2017SGR723 and 2014SGR850), by the Fundación Caja de Ahorros de Asturias, and by the University of Oviedo. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMJ Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | MCC-Spain | es_ES |
dc.subject | Breast cancer | es_ES |
dc.subject | Cohort | es_ES |
dc.subject | Colorectal cancer | es_ES |
dc.subject | Epidemiology | es_ES |
dc.subject | Prostate cancer | es_ES |
dc.title | Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial 4.0 Internacional | * |
dc.identifier.pubmedID | 31753885 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | e031904 | es_ES |
dc.identifier.doi | 10.1136/bmjopen-2019-031904 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación Marqués de Valdecilla | |
dc.contributor.funder | International Cancer Genome Consortium | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Gobierno de la Región de Murcia (España) | |
dc.contributor.funder | European Commission | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Fundación Caja de Ahorros de Asturias | |
dc.contributor.funder | Government of Catalonia (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2044-6055 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1136/bmjopen-2019-031904 | es_ES |
dc.identifier.journal | BMJ open | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1770 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/0533 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1359 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/00773 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01286-León | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01903-Valencia | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/02078-Huelva | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01662-Granada | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01889-FEDER | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00226 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01810 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02213 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00488 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00265 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/01270 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00715 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00150 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/0613 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00069 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00914 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/01032 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI17CIII/00034 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI18/00181 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/API 10/09 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0036 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/LE22A10-2 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI-0571-2009 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI-0306-2011 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/salud201200057018tra | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AP_061/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2010ACUP 00310 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/grants FOOD-CT-2006-036224-HIWATE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/grants 2017SGR723 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/GCTRA18022MORE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2014SGR850 | es_ES |
dc.rights.accessRights | open access | es_ES |
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Este ítem aparece en la(s) siguiente(s) colección(ones)
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IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
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IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)
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IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
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IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
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IDIPHIM - Instituto de Investigación Sanitaria Puerta de Hierro (Madrid)
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IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
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ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
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ISCIII - Artículos