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dc.contributor.author | Gómez-Acebo, Inés | |
dc.contributor.author | Dierssen-Sotos, Trinidad | |
dc.contributor.author | Palazuelos, Camilo | |
dc.contributor.author | Fernandez-Navarro, Pablo L | |
dc.contributor.author | Castaño-Vinyals, Gemma | |
dc.contributor.author | Alonso-Molero, Jéssica | |
dc.contributor.author | Urtiaga, Carmen | |
dc.contributor.author | Fernández-Villa, Tania | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | Rivas-Del-Fresno, Manuel | |
dc.contributor.author | Molina-Barceló, Ana | |
dc.contributor.author | Jimenez-Moleon, Jose J. | |
dc.contributor.author | García-Martinez, Lidia | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Rodríguez-Cundín, Paz | |
dc.contributor.author | Moreno, Víctor | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.contributor.author | Llorca, Javier | |
dc.date.accessioned | 2019-11-27T08:27:46Z | |
dc.date.available | 2019-11-27T08:27:46Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | PLoS One. 2018 Aug 14;13(8):e0201750. | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8715 | |
dc.description.abstract | INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer. | es_ES |
dc.description.sponsorship | This work was partially funded by the “Accion Transversal del Cancer", approved by the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)); The Junta de Castilla y León [LE22A10-2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOOD-CT-2006-036224-HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Aged, 80 and over | es_ES |
dc.subject.mesh | Breast Neoplasms | es_ES |
dc.subject.mesh | Case-Control Studies | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Genetic Predisposition to Disease | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Mendelian Randomization Analysis | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Phenotype | es_ES |
dc.subject.mesh | Pigmentation | es_ES |
dc.subject.mesh | Polymorphism, Single Nucleotide | es_ES |
dc.subject.mesh | Prostatic Neoplasms | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Young Adult | es_ES |
dc.title | Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30106959 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.number | 8 | es_ES |
dc.format.page | e0201750 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0201750 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación Marqués de Valdecilla | |
dc.contributor.funder | International Cancer Genome Consortium | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Gobierno de la Región de Murcia (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Government of Catalonia (España) | |
dc.contributor.funder | Fundación Caja de Ahorros de Asturias | |
dc.contributor.funder | University of Oviedo (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1932-6203 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0201750 | es_ES |
dc.identifier.journal | PloS one | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1770 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/0533 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/I08/1359 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/00773-Cantabria | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01286-León | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01903-Valencia | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/02078-Huelva | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/01662-Granada | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01889-FEDER | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00226 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01810 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02213 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00488 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00265 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/01270 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00715 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00150 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/0613 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00069 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ESPI15/00914 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ESPI15/01032 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0036 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/LE22A10-2 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2009-S0143 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AP_061/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2010ACUP 00310 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/grants FOOD-CT-2006-036224-HIWATE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/grant 2014SGR647 | es_ES |
dc.rights.accessRights | open access | es_ES |
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Este ítem aparece en la(s) siguiente(s) colección(ones)
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IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
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IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
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IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
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Centro Nacional de Epidemiología (CNE)
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ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
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IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
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IDIPHIM - Instituto de Investigación Sanitaria Puerta de Hierro (Madrid)
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IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)