Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20292
Título
Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial
Autor(es)
Fecha de publicación
2016-10-24
Cita
Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Rigo Carratala F, Marti R, et al. Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial. Cardiovasc Diabetol. 2016 Oct 24;15:148.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: The cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arterial stiffness and the risk of cardiovascular diseases. However, the correlation of MetS and its components with arterial stiffness is still not clear. The primary aim of this study is thus the relationship using baPWV and CAVI in Caucasian adults with intermediate cardiovascular risk. The secondary aim is to analyze sex differences. Methods: This study analyzed 2351 subjects aged 35-74 years (mean, 61.4 +/- 7.7 years) comprising 61.7 % males and enrolled in the improving interMediAte Risk management (MARK) study. CAVI was measured using a VaSera VS-1500 (R) device, and baPWV was calculated using a validated equation. MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured. Results: MetS was found in 51.9 % of the subjects. All MetS components except reduced HDL-cholesterol (p = 0.578) were associated with CAVI. High density lipoprotein cholesterol (p = 0.075) and waist circumference (p = 0.315) were associated with baPWV. The different MetS components that assess dyslipidemia using the stiffness measures show different associations according to patient sex. The high blood pressure component had a greater odds ratio (OR) for both baPWV >= 17.5 m/sec (OR = 6.90, 95 % CI 3.52-13.519) and CAVI >= 9 (OR = 2.20, 95 % CI 1.63-1.90). Conclusions: MetS and all its components (except HDL-cholesterol with baPWV and CAVI and WC with baPWV) were associated with baPWV and CAVI. However, there were sex differences in the association of MetS and its components with baPWV and CAVI. Data from this study suggest a greater association of CAVI and baPWV values with MetS components in males than in females and indicate greater arterial stiffness in the event of simultaneously elevated blood pressure, fasting plasma glucose, and waist circumference.
Palabras clave
Metabolic syndrome | Brachial-ankle pulse wave velocity | Cardio-ankle vascular index | Arterial stiffness
MESH
Aged | European Continental Ancestry Group | Humans | Blood Pressure | Cross-Sectional Studies | Prognosis | Lipids | Male | Multivariate Analysis | Biomarkers | Predictive Value of Tests | Chi-Square Distribution | Female | Risk Factors | Cardiovascular Diseases | Metabolic Syndrome | Blood Glucose | Pulse Wave Analysis | Middle Aged | Sex Factors | Vascular Stiffness | Odds Ratio | Ankle Brachial Index | Linear Models | Waist Circumference | Logistic Models
DECS
Modelos Lineales | Modelos Logísticos | Oportunidad Relativa | Femenino | Grupo de Ascendencia Continental Europea | Lípidos | Masculino | Circunferencia de la Cintura | Factores Sexuales | Índice Tobillo Braquial | Persona de Mediana Edad | Glucemia | Rigidez Vascular | Enfermedades Cardiovasculares | Análisis de la Onda del Pulso | Biomarcadores | Distribución de Chi-Cuadrado | Síndrome Metabólico | Análisis Multivariante | Estudios Transversales | Factores de Riesgo | Presión Sanguínea | Humanos | Valor Predictivo de las Pruebas | Pronóstico | Anciano
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