Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20220
Title
Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders
Author(s)
Date issued
2016-01
Citation
Di Minno G, Perno Carlo F, Tiede A, Navarro D, Canaro Hirnyk M, Gueertler L, et al. Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders. Blood Rev. 2016 Jan;30(1):35-48. Epub 2015 Jul 20.
Language
Inglés
Document type
review article
Abstract
The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products.
Subject
MESH
Bacteremia | Blood Coagulation Disorders | Hepacivirus | Hepatitis B virus | Humans | Chromatography, Ion Exchange | Blood Donors | Viremia | Blood-Borne Pathogens | Blood Component Transfusion | Risk | HIV-1 | Fungemia | Ultrafiltration | Parasitemia
DECS
VIH-1 | Parasitemia | Ultrafiltración | Fungemia | Viremia | Transfusión de Componentes Sanguíneos | Patógenos Transmitidos por la Sangre | Donantes de Sangre | Riesgo | Virus de la Hepatitis B | Humanos | Cromatografía por Intercambio Iónico | Bacteriemia | Trastornos de la Coagulación Sanguínea | Hepacivirus
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