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dc.contributor.authorDi Minno, Giovanni
dc.contributor.authorPerno, Carlo Federico
dc.contributor.authorTiede, Andreas
dc.contributor.authorNavarro, David
dc.contributor.authorCanaro Hirnyk, Mariana
dc.contributor.authorGueertler, Lutz
dc.contributor.authorIronside, James W
dc.date.accessioned2024-07-09T09:12:51Z
dc.date.available2024-07-09T09:12:51Z
dc.date.issued2016-01
dc.identifier.citationDi Minno G, Perno Carlo F, Tiede A, Navarro D, Canaro Hirnyk M, Gueertler L, et al. Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders. Blood Rev. 2016 Jan;30(1):35-48. Epub 2015 Jul 20.en
dc.identifier.issn0268-960X
dc.identifier.otherhttp://hdl.handle.net/20.500.13003/17309
dc.identifier.urihttp://hdl.handle.net/20.500.12105/20220
dc.description.abstractThe pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products.en
dc.description.sponsorshipWe wish to thank Professor Hermann Eichler for his appraisal of this manuscript and helpful suggestions. Medical writing assistance was provided by Hanna Mourad-Agha of inScience Communications, Springer Healthcare. This assistance was funded by Pfizer.es_ES
dc.language.isoengen
dc.publisherChurchill Livingstoneen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPathogen
dc.subjectTransfusion
dc.subjectBlood safety
dc.subjectClotting
dc.subjectHaemophilia
dc.subject.meshBacteremia *
dc.subject.meshBlood Coagulation Disorders *
dc.subject.meshHepacivirus *
dc.subject.meshHepatitis B virus *
dc.subject.meshHumans *
dc.subject.meshChromatography, Ion Exchange *
dc.subject.meshBlood Donors *
dc.subject.meshViremia *
dc.subject.meshBlood-Borne Pathogens *
dc.subject.meshBlood Component Transfusion *
dc.subject.meshRisk *
dc.subject.meshHIV-1 *
dc.subject.meshFungemia *
dc.subject.meshUltrafiltration *
dc.subject.meshParasitemia *
dc.titleCurrent concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disordersen
dc.typereview articleen
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.identifier.pubmedID26381318es_ES
dc.format.volume30es_ES
dc.format.number1es_ES
dc.format.page35-48es_ES
dc.identifier.doi10.1016/j.blre.2015.07.004
dc.identifier.e-issn1532-1681es_ES
dc.relation.publisherversionhttps://dx.doi.org/10.1016/j.blre.2015.07.004en
dc.identifier.journalBlood Reviewses_ES
dc.rights.accessRightsopen accessen
dc.subject.decsVIH-1*
dc.subject.decsParasitemia*
dc.subject.decsUltrafiltración*
dc.subject.decsFungemia*
dc.subject.decsViremia*
dc.subject.decsTransfusión de Componentes Sanguíneos*
dc.subject.decsPatógenos Transmitidos por la Sangre*
dc.subject.decsDonantes de Sangre*
dc.subject.decsRiesgo*
dc.subject.decsVirus de la Hepatitis B*
dc.subject.decsHumanos*
dc.subject.decsCromatografía por Intercambio Iónico*
dc.subject.decsBacteriemia*
dc.subject.decsTrastornos de la Coagulación Sanguínea*
dc.subject.decsHepacivirus*
dc.identifier.scopus2-s2.0-84960203756
dc.identifier.wos371362700005
dc.identifier.puiL606042331


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Attribution-NonCommercial-NoDerivatives 4.0 International
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