Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20154
Title
The Genotype of the Donor for the (GT)(n) Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation
Author(s)
Noriega, Victor | Martinez-Laperche, Carolina | Buces, Elena | | Sanchez-Hernandez, Noemi | Martin-Antonio, Beatriz | Guillem, Vicent | Bosch-Vizcaya, Anna | Bento, Leyre | Gonzalez-Rivera, Milagros | Balsalobre, Pascual | Kwon, Mi | Serrano, David | Gayoso, Jorge | de la Cámara, Rafael | Brunet, Salut | Rojas-Contreras, Rafael | Nieto, Jose B. | Martinez, Carmen | Gonzalez, Marcos | Espigado, Ildefonso | Vallejo, Juan C. | Sampol Mayol, Antonia | Jimenez-Velasco, Antonio | Urbano-Ispizua, Alvaro | Solano, Carlos | Gallardo, David | Diez-Martin, Jose L | Buno, Ismael | Spanish Hematopoietic Stem Cell Tr
Date issued
2015-10-16
Citation
Noriega V, Martinez-Laperche C, Buces E, Pion M, Sanchez-Hernandez N, Martin-Antonio B, et al. The Genotype of the Donor for the (GT)(n) Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation. PLoS One. 2015 Oct 16;10(10):e0140454.
Language
Inglés
Document type
research article
Abstract
The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (<=(GT)(15)) for the (GT)(n) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto-or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients.
MESH
Forkhead Transcription Factors | Genotype | Aged | Young Adult | Hematopoietic Stem Cell Transplantation | Transplantation, Homologous | Adult | Humans | Graft vs Leukemia Effect | Middle Aged | Promoter Regions, Genetic | Graft vs Host Disease | Male | Tissue Donors | Female | Genetic Association Studies | Survival Analysis | Polymorphism, Genetic
DECS
Factores de Transcripción Forkhead | Efecto Injerto vs Leucemia | Análisis de Supervivencia | Enfermedad Injerto contra Huésped | Donantes de Tejidos | Femenino | Masculino | Trasplante de Células Madre Hematopoyéticas | Humanos | Persona de Mediana Edad | Adulto Joven | Estudios de Asociación Genética | Regiones Promotoras Genéticas | Anciano | Genotipo | Adulto | Polimorfismo Genético | Trasplante Homólogo
Online version
DOI
Collections
- Investigación > IIS > IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
- Investigación > IIS > INCLIVA - Instituto de Investigación Sanitaria Fundación para la Investigación del Hospital Clínico de Valencia (C. Valenciana)
- Investigación > IIS > IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
- Investigación > IIS > IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón (Madrid)
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