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dc.contributor.author | Noriega, Victor | |
dc.contributor.author | Martinez-Laperche, Carolina | |
dc.contributor.author | Buces, Elena | |
dc.contributor.author | ||
dc.contributor.author | Sanchez-Hernandez, Noemi | |
dc.contributor.author | Martin-Antonio, Beatriz | |
dc.contributor.author | Guillem, Vicent | |
dc.contributor.author | Bosch-Vizcaya, Anna | |
dc.contributor.author | Bento, Leyre | |
dc.contributor.author | Gonzalez-Rivera, Milagros | |
dc.contributor.author | Balsalobre, Pascual | |
dc.contributor.author | Kwon, Mi | |
dc.contributor.author | Serrano, David | |
dc.contributor.author | Gayoso, Jorge | |
dc.contributor.author | de la Cámara, Rafael | |
dc.contributor.author | Brunet, Salut | |
dc.contributor.author | Rojas-Contreras, Rafael | |
dc.contributor.author | Nieto, Jose B. | |
dc.contributor.author | Martinez, Carmen | |
dc.contributor.author | Gonzalez, Marcos | |
dc.contributor.author | Espigado, Ildefonso | |
dc.contributor.author | Vallejo, Juan C. | |
dc.contributor.author | Sampol Mayol, Antonia | |
dc.contributor.author | Jimenez-Velasco, Antonio | |
dc.contributor.author | Urbano-Ispizua, Alvaro | |
dc.contributor.author | Solano, Carlos | |
dc.contributor.author | Gallardo, David | |
dc.contributor.author | Diez-Martin, Jose L | |
dc.contributor.author | Buno, Ismael | |
dc.contributor.author | Spanish Hematopoietic Stem Cell Tr | |
dc.date.accessioned | 2024-07-04T12:56:31Z | |
dc.date.available | 2024-07-04T12:56:31Z | |
dc.date.issued | 2015-10-16 | |
dc.identifier.citation | Noriega V, Martinez-Laperche C, Buces E, Pion M, Sanchez-Hernandez N, Martin-Antonio B, et al. The Genotype of the Donor for the (GT)(n) Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation. PLoS One. 2015 Oct 16;10(10):e0140454. | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10659 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20154 | |
dc.description.abstract | The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (<=(GT)(15)) for the (GT)(n) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto-or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients. | en |
dc.description.sponsorship | This work was partially supported by the Ministry of Economy and Competitiveness ISCIII-FIS grants PI08/1463, PI11/00708, PI14-01731 and RD12/0036/0061, co-financed by ERDF (FEDER) Funds from the European Commission, as well as grants from the Fundacion LAIR and Asociacion Madrilena de Hematologia y Hemoterapia (AMHH). Sequencer 3130xl Genetic Analyzer was partially supported by ISCIII-FIS grants PI01-3624, PI08-36173. VN and CML were partially supported by a Post-Residency Research Fellowship from the Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM). | es_ES |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science (PLOS) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Forkhead Transcription Factors | * |
dc.subject.mesh | Genotype | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Hematopoietic Stem Cell Transplantation | * |
dc.subject.mesh | Transplantation, Homologous | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Graft vs Leukemia Effect | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Promoter Regions, Genetic | * |
dc.subject.mesh | Graft vs Host Disease | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Tissue Donors | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Genetic Association Studies | * |
dc.subject.mesh | Survival Analysis | * |
dc.subject.mesh | Polymorphism, Genetic | * |
dc.title | The Genotype of the Donor for the (GT)(n) Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 26473355 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 10 | es_ES |
dc.format.page | e0140454 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0140454 | |
dc.relation.publisherversion | https://dx.doi.org/10.1371/journal.pone.0140454 | en |
dc.identifier.journal | PloS One | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Factores de Transcripción Forkhead | * |
dc.subject.decs | Efecto Injerto vs Leucemia | * |
dc.subject.decs | Análisis de Supervivencia | * |
dc.subject.decs | Enfermedad Injerto contra Huésped | * |
dc.subject.decs | Donantes de Tejidos | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Trasplante de Células Madre Hematopoyéticas | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Adulto Joven | * |
dc.subject.decs | Estudios de Asociación Genética | * |
dc.subject.decs | Regiones Promotoras Genéticas | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Genotipo | * |
dc.subject.decs | Adulto | * |
dc.subject.decs | Polimorfismo Genético | * |
dc.subject.decs | Trasplante Homólogo | * |
dc.identifier.scopus | 2-s2.0-84949220859 | |
dc.identifier.wos | 363185500054 | |
dc.identifier.pui | L607132865 |
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Este ítem aparece en la(s) siguiente(s) colección(ones)
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IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
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INCLIVA - Instituto de Investigación Sanitaria Fundación para la Investigación del Hospital Clínico de Valencia (C. Valenciana)
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IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
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IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón (Madrid)