Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20101
Title
Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study
Author(s)
Chajes, Veronique | Biessy, Carine | Ferrari, Pietro | Romieu, Isabelle | Freisling, Heinz | Huybrechts, Inge | Scalbert, Augustin | de Mesquita, Bas Bueno | Romaguera, Dora | Gunter, Marc J | Vineis, Paolo | Hansen, Camilla Plambeck | Jakobsen, Marianne Uhre | Clavel-Chapelon, Francoise | Fagherazzi, Guy | Boutron-Ruault, Marie-Christine | Katzke, Verana | Neamat-Allah, Jasmine | Boeing, Heiner | Bachlechner, Ursula | Trichopoulou, Antonia | Naska, Androniki | Orfanos, Philippos | Pala, Valeria | Masala, Giovanna | Mattiello, Amalia | Skeie, Guri | Weiderpass, Elisabete | Agudo, Antonio | Maria Huerta, Jose | Ardanaz, Eva | Jose Sanchez, Maria | Dorronsoro, Miren | Ramon Quiros, Jose | Johansson, Ingegerd | Winkvist, Anna | Sonested, Emily | Key, Tim | Khaw, Kay-Tee | Wareham, Nicolas J. | Peeters, Petra H. M. | Slimani, Nadia
Date issued
2015-02-12
Citation
Chajes V, Biessy C, Ferrari P, Romieu I, Freisling H, Huybrechts I, et al. Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study. PLoS One. 2015 Feb 12;10(2):e0118206.
Language
Inglés
Document type
research article
Abstract
Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region. Results: In women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend<. 0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss ( OR = 0.82, 95% CI = 0.66- 1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5- year follow- up ( OR = 1.08, 95% CI = 0.88- 1.33, p = 0.454). No association was found for saturated and cismonounsaturated fatty acids. Conclusions: These data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially- produced trans fatty acids.
MESH
Trans Fatty Acids | Oleic Acids | Body Weight | Follow-Up Studies | Humans | Public Health Surveillance | Obesity | Male | Biomarkers | Prospective Studies | Europe | Female | Risk | Oleic Acid | Surveys and Questionnaires
DECS
Biomarcadores | Ácidos Grasos trans | Femenino | Europa (Continente) | Masculino | Vigilancia en Salud Pública | Estudios de Seguimiento | Riesgo | Humanos | Obesidad | Estudios Prospectivos | Encuestas y Cuestionarios | Ácido Oléico | Ácidos Oléicos | Peso Corporal
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