Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20095
Title
Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation
Author(s)
Balcells, Eva | Gimeno-Santos, Elena | de Batlle, Jordi | Antonia Ramon, Maria | Rodriguez, Esther | Benet, Marta | Farrero, Eva | Ferrer, Antoni | Guerra, Stefano | Ferrer, Jaume | Sauleda, Jaume | Barbera, Joan A. | Agusti, Alvar | Rodriguez-Roisin, Robert | Gea, Joaquim | Anto, Josep M. | Garcia-Aymerich, Judith | PAC-COPD Study Grp
Date issued
2015-01-17
Citation
Balcells E, Gimeno-Santos E, De Batlle J, Ramon MA, Rodriguez E, Benet M, et al. Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation. BMC Pulm Med. 2015 Jan 17;15:4.
Language
Inglés
Document type
research article
Abstract
Background: Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD. Methods: The PAC-COPD cohort included 342 COPD patients hospitalised for the first time for an exacerbation of COPD (2004-2006). Patients were extensively characterised using sociodemographic, clinical and functional variables, and the cohort was followed-up through 2008. We defined undiagnosed COPD by the absence of any self-reported respiratory disease and regular use of any pharmacological respiratory treatment. Results: Undiagnosed COPD was present in 34% of patients. They were younger (mean age 66 vs. 68 years, p = 0.03), reported fewer symptoms (mMRC dyspnoea score, 2.1 vs. 2.6, p < 0.01), and had a better health status (SGRQ total score, 29 vs. 40, p < 0.01), milder airflow limitation (FEV1% ref., 59% vs. 49%, p < 0.01), and fewer comorbidities (two or more, 40% vs. 56%, p < 0.01) when compared with patients with an established COPD diagnosis. Three months after hospital discharge, 16% of the undiagnosed COPD patients had stopped smoking (vs. 5%, p = 0.019). During follow-up, annual hospitalisation rates were lower in undiagnosed COPD patients (0.14 vs. 0.25, p < 0.01); however, this difference disappeared after adjustment for severity. Mortality was similar in both groups. Conclusions: Undiagnosed COPD patients have less severe disease and lower risk of re-hospitalisation when compared with hospitalised patients with known COPD.
Subject
Pulmonary disease | Chronic obstructive | Hospitalisation | Cohort studies | Epidemiology | Health services
MESH
Aged | Dyspnea | Pulmonary Disease, Chronic Obstructive | Follow-Up Studies | Humans | Health Status | Forced Expiratory Volume | Middle Aged | Tobacco Use | Longitudinal Studies | Prognosis | Hospitalization | Male | Self Report | Severity of Illness Index | Female | Smoking Cessation | Comorbidity | Patient Discharge | Surveys and Questionnaires
DECS
Comorbilidad | Femenino | Uso de Tabaco | Hospitalización | Masculino | Estudios de Seguimiento | Volumen Espiratorio Forzado | Enfermedad Pulmonar Obstructiva Crónica | Estudios Longitudinales | Humanos | Persona de Mediana Edad | Estado de Salud | Pronóstico | Anciano | Índice de Severidad de la Enfermedad | Encuestas y Cuestionarios | Disnea | Alta del Paciente | Autoinforme | Cese del Hábito de Fumar
Online version
DOI
Collections
- Investigación > IIS > IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > IIS > IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
Full text access