Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20083
Título
Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.
Autor(es)
Lopez, Aurelio | Mateos, Maria-Victoria | Oriol, Albert | Valero, Marta | Martinez, Joaquin | Lorenzo, Jose Ignacio | Perez, Montserrat | Martinez, Rafael | de Paz, Raquel | Granell, Miguel | de Arriba, Felipe | Blanchard, M Jesus | Penalver, Francisco-Javier | Bello, Jose Luis | Martin, Maria Luisa | Bargay Lleonart, Joan | Blade, Joan | Lahuerta, Juan Jose | San Miguel, Jesus F | de la Rubia Comos, Javier
Fecha de publicación
2015
Cita
Lopez A, Mateos MV, Oriol A, Valero M, Martinez J, Lorenzo JI, et al. Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.. Leuk Res Rep. 2015;4(2):64-9.
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research article
Resumen
We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).
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