Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20083
Title
Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.
Author(s)
Lopez, Aurelio | Mateos, Maria-Victoria | Oriol, Albert | Valero, Marta | Martinez, Joaquin | Lorenzo, Jose Ignacio | Perez, Montserrat | Martinez, Rafael | de Paz, Raquel | Granell, Miguel | de Arriba, Felipe | Blanchard, M Jesus | Penalver, Francisco-Javier | Bello, Jose Luis | Martin, Maria Luisa | Bargay Lleonart, Joan | Blade, Joan | Lahuerta, Juan Jose | San Miguel, Jesus F | de la Rubia Comos, Javier
Date issued
2015
Citation
Lopez A, Mateos MV, Oriol A, Valero M, Martinez J, Lorenzo JI, et al. Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.. Leuk Res Rep. 2015;4(2):64-9.
Language
Inglés
Document type
research article
Abstract
We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).
Subject
Online version
DOI
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