Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20010
Title
How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry
Author(s)
Date issued
2014-09
Citation
Sabater S, Berenguer R, Honrubia-Gomez P, Rivera M, Nunez A, Jimenez-Jimenez E, et al. How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry. J Radiat Res. 2014 Sep;55(5):1009-14. Epub 2014 Apr 10.
Language
Inglés
Document type
research article
Abstract
Radiation of experimental culture cells on plates with various wells can cause a risk of underdosage as a result of the existence of multiple air-water interfaces. The objective of our study was to quantify this error in culture plates with multiple wells. Radiation conditions were simulated with the GAMOS code, based on the GEANT4 code, and this was compared with a simulation performed with PENELOPE and measured data. We observed a slight underdosage of similar to 4% on the most superficial half of the culture medium. We believe that this underdosage does not have a significant effect on the dose received by culture cells deposited in a monolayer and adhered to the base of the wells.
Subject
MESH
Cell Culture Techniques | Absorption, Radiation | Cell Physiological Phenomena | Equipment Design | Monte Carlo Method | Animals | Humans | Models, Statistical | Air | Equipment Failure Analysis | Scattering, Radiation | Computer Simulation
DECS
Modelos Estadísticos | Animales | Simulación por Computador | Análisis de Falla de Equipo | Humanos | Aire | Fenómenos Fisiológicos Celulares | Absorción de Radiación | Diseño de Equipo | Dispersión de Radiación | Método de Montecarlo | Técnicas de Cultivo de Célula
Online version
DOI
Collections
Full text access