Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/19065
Title
Molecular effects of polystyrene nanoplastics on human neural stem cells
Author(s)
Martin-Folgar, Raquel | González-Caballero, MCarmen ISCIII | Torres-Ruiz, Mónica ISCIII | Cañas Portilla, Ana Isabel ISCIII | De Alba-González, Mercedes ISCIII | Liste-Noya, Isabel ISCIII | Morales, Mónica
Date issued
2024
Citation
PLoS One. 2024 Jan 3;19(1):e0295816.
Language
Inglés
Document type
research article
Abstract
Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.
MESH
Neural Stem Cells | Water Pollutants, Chemical | Nanoparticles | Animals | Humans | Microplastics | Polystyrenes | Apoptosis | Food Chain
Description
All Results NPs cells files are available from the Dryad repository (doi:10.5061/dryad.zpc866tf9).
Online version
DOI
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