Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/19065
Título
Molecular effects of polystyrene nanoplastics on human neural stem cells
Autor(es)
Martin-Folgar, Raquel | González-Caballero, MCarmen ISCIII | Torres-Ruiz, Mónica ISCIII | Cañas Portilla, Ana Isabel ISCIII | De Alba-González, Mercedes ISCIII | Liste-Noya, Isabel ISCIII | Morales, Mónica
Fecha de publicación
2024
Cita
PLoS One. 2024 Jan 3;19(1):e0295816.
Idioma
Inglés
Tipo de documento
research article
Resumen
Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.
MESH
Neural Stem Cells | Water Pollutants, Chemical | Nanoparticles | Animals | Humans | Microplastics | Polystyrenes | Apoptosis | Food Chain
Descripción
All Results NPs cells files are available from the Dryad repository (doi:10.5061/dryad.zpc866tf9).
Versión en línea
DOI
Aparece en las colecciones