Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/17951
Title
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.
Author(s)
Murga, Matilde CNIO | Campaner, Stefano | Lopez-Contreras, Andres J | Toledo, Luis I | Soria, Rebeca | Montaña, Maria F | Artista, Luana D' | Schleker, Thomas | Guerra, Carmen CNIO | Garcia, Elena | Barbacid, Mariano CNIO | Hidalgo, Manuel CNIO | Amati, Bruno | Fernandez-Capetillo, Oscar CNIO
Date issued
2011-11-27
Citation
Nat Struct Mol Biol . 2011 ;18(12):1331-1335.
Language
Inglés
Document type
journal article
Abstract
Oncogene-induced replicative stress activates an Atr- and Chk1-dependent response, which has been proposed to be widespread in tumors. We explored whether the presence of replicative stress could be exploited for the selective elimination of cancer cells. To this end, we evaluated the impact of targeting the replicative stress-response on cancer development. In mice (Mus musculus), the reduced levels of Atr found on a mouse model of the Atr-Seckel syndrome completely prevented the development of Myc-induced lymphomas or pancreatic tumors, both of which showed abundant levels of replicative stress. Moreover, Chk1 inhibitors were highly effective in killing Myc-driven lymphomas. By contrast, pancreatic adenocarcinomas initiated by K-Ras(G12V) showed no detectable evidence of replicative stress and were nonresponsive to this therapy. Besides its impact on cancer, Myc overexpression aggravated the phenotypes of Atr-Seckel mice, revealing that oncogenes can modulate the severity of replicative stress-associated diseases.
MESH
Stress, Physiological | Adenocarcinoma | Animals | Antineoplastic Agents | Apoptosis | Ataxia Telangiectasia Mutated Proteins | Cell Cycle Proteins | Checkpoint Kinase 1 | DNA Damage | Lymphoma | Mice | Pancreatic Neoplasms | Protein Kinase Inhibitors | Protein Kinases | Protein Serine-Threonine Kinases | Proto-Oncogene Proteins c-myc
Online version
DOI
Collections