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A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells
A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors
A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.
ATR expands embryonic stem cell fate potential in response to replication stress.
ATR is required to complete meiotic recombination in mice
Efficacy of ATR inhibitors as single agents in Ewing sarcoma
ERF deletion rescues RAS deficiency in mouse embryonic stem cells
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.
Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells
POLD3 Is Haploinsufficient for DNA Replication in Mice
Replication stress caused by low MCM expression limits fetal
erythropoiesis and hematopoietic stem cell functionality
The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity
TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress