dc.contributor.author | Domenech, Arnau | |
dc.contributor.author | Ardanuy, Carmen | |
dc.contributor.author | Pallarés, Román | |
dc.contributor.author | Grau, Immaculada | |
dc.contributor.author | Santos, Salud | |
dc.contributor.author | de la Campa, Adela G | |
dc.contributor.author | Liñares, Josefina | |
dc.date.accessioned | 2021-04-27T14:53:29Z | |
dc.date.available | 2021-04-27T14:53:29Z | |
dc.date.issued | 2013-03 | |
dc.identifier.citation | PLoS One. 2013;8(3):e59027. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/12782 | |
dc.description.abstract | To analyze the role of the capsular type in pneumococci causing relapse and reinfection episodes of acute exacerbation in COPD patients.
A total of 79 patients with 116 recurrent episodes of acute exacerbations caused by S. pneumoniae were included into this study (1995-2010). A relapse episode was considered when two consecutive episodes were caused by the same strain (identical serotype and genotype); otherwise it was considered reinfection. Antimicrobial susceptibility testing (microdilution), serotyping (PCR, Quellung) and molecular typing (PFGE/MLST) were performed.
Among 116 recurrent episodes, 81 (69.8%) were reinfections, caused by the acquisition of a new pneumococcus, and 35 (30.2%) were relapses, caused by a pre-existing strain. Four serotypes (9V, 19F, 15A and 11A) caused the majority (60.0%) of relapses. When serotypes causing relapses and reinfection were compared, only two serotypes were associated with relapses: 9V (OR 8.0; 95% CI, 1.34-85.59) and 19F (OR 16.1; 95% CI, 1.84-767.20). Pneumococci isolated from relapses were more resistant to antimicrobials than those isolated from the reinfection episodes: penicillin (74.3% vs. 34.6%, p<0.001), ciprofloxacin (25.7% vs. 9.9%, p<0.027), levofloxacin (22.9% vs. 7.4%, p = 0.029), and co-trimoxazole (54.3% vs. 25.9%, p<0.001).
Although the acquisition of a new S. pneumoniae strain was the most frequent cause of recurrences, a third of the recurrent episodes were caused by a pre-existing strain. These relapse episodes were mainly caused by serotypes 9V and 19F, suggesting an important role for capsular type. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Fondo de Investigaciones Sanitarias de la Seguridad Social [PI 0901904], by grants [BIO2008-02154 and BIO2011-25343] from Plan Nacional de I+D+I of Ministerio de Ciencia e Innovación, and by CIBER de Enfermedades Respiratorias, CIBERES; [CB06/06/0037], run by the Instituto de Salud Carlos III (ISCIII), Madrid, Spain. A. D. was supported by a grant from Formaci?n de Profesorado Universitario (FPU; Ministerio de Educación, Spain). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Microbial Sensitivity Tests | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Multilocus Sequence Typing | es_ES |
dc.subject.mesh | Pneumococcal Infections | es_ES |
dc.subject.mesh | Pulmonary Disease, Chronic Obstructive | es_ES |
dc.subject.mesh | Recurrence | es_ES |
dc.subject.mesh | Serotyping | es_ES |
dc.subject.mesh | Streptococcus pneumoniae | es_ES |
dc.title | Some pneumococcal serotypes are more frequently associated with relapses of acute exacerbations in COPD patients. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 23536850 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | e59027 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0059027 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Ministerio de Educación (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1932-6203 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0059027 | es_ES |
dc.identifier.journal | PloS one | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI 0901904 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BIO2008-02154 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BIO2011-25343 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CB06/06/0037 | es_ES |
dc.rights.accessRights | open access | es_ES |