Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/12593
Título
Sarcoma classification by DNA methylation profiling.
Autor(es)
Koelsche, Christian | Schrimpf, Daniel | Stichel, Damian | Sill, Martin | Sahm, Felix | Reuss, David E | Blattner, Mirjam | Worst, Barbara | Heilig, Christoph E | Beck, Katja | Horak, Peter | Kreutzfeldt, Simon | Paff, Elke | Stark, Sebastian | Johann, Pascal | Selt, Florian | Ecker, Jonas | Sturm, Dominik | Pajtler, Kristian W | Reinhardt, Annekathrin | Wefers, Annika K | Sievers, Philipp | Ebrahimi, Azadeh | Suwala, Abigail | Fernández-Klett, Francisco | Casalini, Belén | Korshunov, Andrey | Hovestadt, Volker | Kommoss, Felix K F | Kriegsmann, Mark | Schick, Matthias | Bewerunge-Hudler, Melanie | Milde, Till | Witt, Olaf | Kulozik, Andreas E | Kool, Marcel | Romero-Pérez, Laura | Grünewald, Thomas G P | Kirchner, Thomas | Wick, Wolfgang | Platten, Michael | Unterberg, Andreas | Uhl, Matthias | Abdollahi, Amir | Debus, Jürgen | Lehner, Burkhard | Thomas, Christian | Hasselblatt, Martin | Paulus, Werner | Hartmann, Christian | Staszewski, Ori | Prinz, Marco | Hench, Jürgen | Frank, Stephan | Versleijen-Jonkers, Yvonne M H | Weidema, Marije E | Mentzel, Thomas | Griewank, Klaus | de Álava, Enrique | Martín, Juan Díaz | Gastearena, Miguel A Idoate | Chang, Kenneth Tou-En | Low, Sharon Yin Yee | Cuevas-Bourdier, Adrian | Mittelbronn, Michel | Mynarek, Martin | Rutkowski, Stefan | Schüller, Ulrich | Mautner, Viktor F | Schittenhelm, Jens | Serrano, Jonathan | Snuderl, Matija | Büttner, Reinhard | Klingebiel, Thomas | Buslei, Rolf | Gessler, Manfred | Wesseling, Pieter | Dinjens, Winand N M | Brandner, Sebastian | Jaunmuktane, Zane | Lyskjær, Iben | Schirmacher, Peter | Stenzinger, Albrecht | Brors, Benedikt | Glimm, Hanno | Heining, Christoph | Tirado, Oscar M | Sáinz-Jaspeado, Miguel | Mora, Jaume | Alonso, Javier ISCIII | Del Muro, Xavier Garcia | Moran, Sebastian | Esteller, Manel | Benhamida, Jamal K | Ladanyi, Marc | Wardelmann, Eva | Antonescu, Cristina | Flanagan, Adrienne | Dirksen, Uta | Hohenberger, Peter | Baumhoer, Daniel | Hartmann, Wolfgang | Vokuhl, Christian | Flucke, Uta | Petersen, Iver | Mechtersheimer, Gunhild | Capper, David | Jones, David T W | Fröhling, Stefan | Pfister, Stefan M | von Deimling, Andreas
Fecha de publicación
2021
Cita
Nat Commun . 2021 Jan 21;12(1):498.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.
MESH
Algorithms | DNA Methylation | Machine Learning | Bone Neoplasms | Cohort Studies | DNA Copy Number Variations | Humans | Internet | Reproducibility of Results | Sarcoma | Sensitivity and Specificity | Soft Tissue Neoplasms
Versión en línea
DOI
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- SarcomaClassificationByDNA_2021.pdf
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