2024-03-29T10:00:39Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/125932022-10-25T11:03:17Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2102com_20.500.12105_2052col_20.500.12105_16962col_20.500.12105_16958col_20.500.12105_2103
00925njm 22002777a 4500
dc
Koelsche, Christian
author
Schrimpf, Daniel
author
Stichel, Damian
author
Sill, Martin
author
Sahm, Felix
author
Reuss, David E
author
Blattner, Mirjam
author
Worst, Barbara
author
Heilig, Christoph E
author
Beck, Katja
author
Horak, Peter
author
Kreutzfeldt, Simon
author
Paff, Elke
author
Stark, Sebastian
author
Johann, Pascal
author
Selt, Florian
author
Ecker, Jonas
author
Sturm, Dominik
author
Pajtler, Kristian W
author
Reinhardt, Annekathrin
author
Wefers, Annika K
author
Sievers, Philipp
author
Ebrahimi, Azadeh
author
Suwala, Abigail
author
Fernández-Klett, Francisco
author
Casalini, Belén
author
Korshunov, Andrey
author
Hovestadt, Volker
author
Kommoss, Felix K F
author
Kriegsmann, Mark
author
Schick, Matthias
author
Bewerunge-Hudler, Melanie
author
Milde, Till
author
Witt, Olaf
author
Kulozik, Andreas E
author
Kool, Marcel
author
Romero-Pérez, Laura
author
Grünewald, Thomas G P
author
Kirchner, Thomas
author
Wick, Wolfgang
author
Platten, Michael
author
Unterberg, Andreas
author
Uhl, Matthias
author
Abdollahi, Amir
author
Debus, Jürgen
author
Lehner, Burkhard
author
Thomas, Christian
author
Hasselblatt, Martin
author
Paulus, Werner
author
Hartmann, Christian
author
Staszewski, Ori
author
Prinz, Marco
author
Hench, Jürgen
author
Frank, Stephan
author
Versleijen-Jonkers, Yvonne M H
author
Weidema, Marije E
author
Mentzel, Thomas
author
Griewank, Klaus
author
de Álava, Enrique
author
Martín, Juan Díaz
author
Gastearena, Miguel A Idoate
author
Chang, Kenneth Tou-En
author
Low, Sharon Yin Yee
author
Cuevas-Bourdier, Adrian
author
Mittelbronn, Michel
author
Mynarek, Martin
author
Rutkowski, Stefan
author
Schüller, Ulrich
author
Mautner, Viktor F
author
Schittenhelm, Jens
author
Serrano, Jonathan
author
Snuderl, Matija
author
Büttner, Reinhard
author
Klingebiel, Thomas
author
Buslei, Rolf
author
Gessler, Manfred
author
Wesseling, Pieter
author
Dinjens, Winand N M
author
Brandner, Sebastian
author
Jaunmuktane, Zane
author
Lyskjær, Iben
author
Schirmacher, Peter
author
Stenzinger, Albrecht
author
Brors, Benedikt
author
Glimm, Hanno
author
Heining, Christoph
author
Tirado, Oscar M
author
Sáinz-Jaspeado, Miguel
author
Mora, Jaume
author
Alonso, Javier
author
Del Muro, Xavier Garcia
author
Moran, Sebastian
author
Esteller, Manel
author
Benhamida, Jamal K
author
Ladanyi, Marc
author
Wardelmann, Eva
author
Antonescu, Cristina
author
Flanagan, Adrienne
author
Dirksen, Uta
author
Hohenberger, Peter
author
Baumhoer, Daniel
author
Hartmann, Wolfgang
author
Vokuhl, Christian
author
Flucke, Uta
author
Petersen, Iver
author
Mechtersheimer, Gunhild
author
Capper, David
author
Jones, David T W
author
Fröhling, Stefan
author
Pfister, Stefan M
author
von Deimling, Andreas
author
2021
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.
Nat Commun . 2021 Jan 21;12(1):498.
http://hdl.handle.net/20.500.12105/12593
33479225
10.1038/s41467-020-20603-4
2041-1723
Nature communications
Sarcoma classification by DNA methylation profiling.