Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/9562
Crimean-Congo haemorrhagic fever (CCHF) virus-specific antibody detection in blood donors, Castile-León, Spain, summer 2017 and 2018
Monsalve Arteaga, Lía | Muñoz Bellido, Juan Luis | Vieira Lista, María Carmen | Vicente Santiago, María Belén | Fernández Soto, Pedro | Bas, Isabel ISCIII | Leralta, Nuria ISCIII | De Ory, Fernando ISCIII | Negredo, Anabel ISCIII | Sanchez-Seco, Paz ISCIII | Alonso Sardón, Montserrat | Pérez González, Sonia | Jiménez Del Bianco, Ana | Blanco Peris, Lydia | Alamo-Sanz, Rufino | Hewson, Roger | Belhassen-García, Moncef | Muro, Antonio
Euro Surveill. 2020 Mar;25(10).
BackgroundCrimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging or even a probable re-emerging pathogen in southern Europe. Presence of this virus had been reported previously in Spain in 2010.AimWe aimed to evaluate the potential circulation of CCHFV in western Spain with a serosurvey in asymptomatic adults (blood donors).MethodsDuring 2017 and 2018, we conducted a CCHFV serosurvey in randomly selected asymptomatic blood donors from western Spain. Three assays using specific IgG antibodies against CCHFV were performed: the VectoCrimea ELISA test, an in-house ELISA and indirect immunofluorescence (EuroImmun) test with glycoprotein and nucleoprotein.ResultsA total of 516 blood donors participated in this cross-sectional study. The majority of the study participants were male (68.4%), and the mean age was 46.3 years. Most of the participants came from rural areas (86.8%) and 68.6% had contact with animals and 20.9% had animal husbandry practices. One in five participants (109/516, 21.1%) were engaged in at-risk professional activities such as agriculture and shepherding, slaughtering, hunting, veterinary and healthcare work (mainly nursing staff and laboratory technicians). A total of 15.3% of the participants were bitten by ticks in the days or months before the date of sampling. We detected anti-CCHFV IgG antibodies with two diagnostic assays in three of the 516 individuals and with one diagnostic assay in six of the 516 individuals.ConclusionSeroprevalence of CCHFV was between 0.58% and 1.16% in Castile-León, Spain. This is the first study in western Spain that showed circulation of CCHFV in healthy people.
CCHF | Crimean-Congo haemorrhagic fever | blood donor | emerging diseases | epidemiology | laboratory | re-emerging diseases | tick-borne diseases | viral haemorrhagic fever
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