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dc.contributor.authorPastor-Barriuso, Roberto 
dc.contributor.authorFernández, Mariana F
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorWhelan, Denis
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorLlorca, Javier
dc.contributor.authorVillanueva, Cristina M
dc.contributor.authorGuevara, Marcela
dc.contributor.authorMolina-Molina, José-Manuel
dc.contributor.authorArtacho-Cordón, Francisco
dc.contributor.authorBarriuso Lapresa, Laura
dc.contributor.authorTusquets, Ignasi
dc.contributor.authorDierssen-Sotos, Trinidad
dc.contributor.authorAragones, Nuria 
dc.contributor.authorOlea, Nicolás
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorPollan-Santamaria, Marina
dc.identifier.citationEnviron Health Perspect. 2016 Oct;124(10):1575-1582.es_ES
dc.description.abstractBACKGROUND: Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES: We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. METHODS: A total of 186 incident pretreatment breast cancer cases and 196 frequency-matched controls were randomly sampled from a large population-based multicase-control study in Spain. The total effective xenoestrogen burden attributable to organohalogenated xenoestrogens (TEXB-α) and endogenous hormones and more polar xenoestrogens (TEXB-β) was determined in serum samples using high-performance liquid chromatography and E-Screen bioassay. Odds ratios for breast cancer comparing tertiles of serum TEXB-α and TEXB-β were estimated using logistic models, and smooth risk trends were obtained using spline models. RESULTS: Cases had higher geometric mean TEXB-α and TEXB-β levels (8.32 and 9.94 Eeq pM/mL, respectively) than controls (2.99 and 5.96 Eeq pM/mL, respectively). The fully adjusted odds ratios for breast cancer (95% confidence intervals) comparing the second and third tertiles of TEXB-α with the first tertile were 1.77 (0.76, 4.10) and 3.45 (1.50, 7.97), respectively, and those for TEXB-β were 2.35 (1.10, 5.03) and 4.01 (1.88, 8.56), respectively. A steady increase in risk was evident across all detected TEXB-α levels and a sigmoidal trend was observed for TEXB-β. Individual xenoestrogens showed weak and opposing associations with breast cancer risk. CONCLUSIONS: This is the first study to show a strong positive association between serum total xenoestrogen burden and breast cancer risk, highlighting the importance of evaluating xenoestrogen mixtures, rather than single compounds, when studying hormone-related cancers. CITATION: Pastor-Barriuso R, Fernández MF, Castaño-Vinyals G, Whelan D, Pérez-Gómez B, Llorca J, Villanueva CM, Guevara M, Molina-Molina JM, Artacho-Cordón F, Barriuso-Lapresa L, Tusquets I, Dierssen-Sotos T, Aragonés N, Olea N, Kogevinas M, Pollán M. 2016. Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. Environ Health Perspect 124:1575-1582;
dc.description.sponsorshipThis study was partially supported by Acción Transversal del Cancer, approved by the Spanish Ministry Council on 11 October 2007; Carlos III Institute of Health (grants PI08/1770, PI09/00773-Cantabria, PI11/00610, PI12/00265, PI12/00488, PI12/00715, and PI12/01270); and Fundación Marqués de Valdecilla (grant API 10/09). Biological samples were stored at biobanks supported by the Carlos III Institute of Health and the European Regional Development Fund (MAR Biobank RD09/0076/00036 and ISCIII Biobank RD09/0076/00108).es_ES
dc.publisherNational Institute of Environmental Health Sciences (NIEHS) es_ES
dc.titleTotal Effective Xenoestrogen Burden in Serum Samples and Risk for Breast Cancer in a Population-Based Multicase-Control Study in Spaines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFundación Marqués de Valdecilla 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.identifier.journalEnvironmental health perspectiveses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/API 10/09es_ES
dc.rights.accessRightsopen accesses_ES

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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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