Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8709
New species genetic approach to identify strains of mitis group streptococci that are donors of rifampin resistance to Streptococcus pneumoniae
Antimicrob Agents Chemother. 2011 Jan;55(1):368-72. doi: 10.1128/AAC.00856-10. Epub 2010 Nov 1.
Eight rifampin-resistant streptococci of the mitis group were identified at the species level by using a concatenated 16S rRNA gene-sodA-rpoB-hlpA sequence. Characterization of their rpoB alleles showed single amino acid changes involved in rifampin resistance. Comparison of RpoB sequences from pneumococcal recombinant isolates, viridans isolates, and type strains revealed a species-specific amino acid signature, which allowed it to be ascertained that recombinant RpoBs were originated in genetic interchanges with Streptococcus mitis and Streptococcus oralis.
Anti-Bacterial Agents | Drug Resistance, Bacterial | Phylogeny | RNA, Ribosomal, 16S | Rifampin | Streptococcus mitis | Streptococcus oralis | Streptococcus pneumoniae
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